FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014651504> ?p ?o ?g. }

• W2014651504 endingPage "S32" @default.
• W2014651504 startingPage "S26" @default.
• W2014651504 abstract "Objective To review the current data that support the pivotal function of the gastrointestinal immune system in health and disease and its critical role in the pathogenesis of a wide variety of clinical disorders associated with food allergy (FA). Data Sources Internet-based literature search and our own data. Study Selection The studies included in this review were selected based on the expert opinion of the authors. Results In contrast to the beneficial expressions of gastrointestinal-associated lymphoid tissue, which are seen with relevance to newer methods of delivery of vaccines directly applied to the gastrointestinal mucosal surfaces (eg, oral poliovirus, rotavirus, Salmonella typhi vaccines), the adverse consequences of a mucosal immune response gone astray are evidenced in many diseases such as FA. A classification of clinical disorders associated with FA based on classic mechanisms of immunologic injury is presented, which includes the following: (1) IgE-mediated, (2) non-IgE-mediated, and (3) mixed IgE- and non-IgE-mediated disorders. Our study of immunologic disturbance in patients with non-IgE FA revealed a pattern of increased CD4+ and decreased TH1 cell counts in peripheral blood mononuclear cells in contrast to patients with celiac disease, where a pattern of increased CD8+ and TH1 cell counts in peripheral blood mononuclear cells and increased CD8+ cell counts was seen. Conclusions The gastrointestinal immune response thus plays a pivotal role in maintaining protective immunity in health and a critical role in the pathogenesis of a wide variety of clinical disorders associated with FA. To review the current data that support the pivotal function of the gastrointestinal immune system in health and disease and its critical role in the pathogenesis of a wide variety of clinical disorders associated with food allergy (FA). Internet-based literature search and our own data. The studies included in this review were selected based on the expert opinion of the authors. In contrast to the beneficial expressions of gastrointestinal-associated lymphoid tissue, which are seen with relevance to newer methods of delivery of vaccines directly applied to the gastrointestinal mucosal surfaces (eg, oral poliovirus, rotavirus, Salmonella typhi vaccines), the adverse consequences of a mucosal immune response gone astray are evidenced in many diseases such as FA. A classification of clinical disorders associated with FA based on classic mechanisms of immunologic injury is presented, which includes the following: (1) IgE-mediated, (2) non-IgE-mediated, and (3) mixed IgE- and non-IgE-mediated disorders. Our study of immunologic disturbance in patients with non-IgE FA revealed a pattern of increased CD4+ and decreased TH1 cell counts in peripheral blood mononuclear cells in contrast to patients with celiac disease, where a pattern of increased CD8+ and TH1 cell counts in peripheral blood mononuclear cells and increased CD8+ cell counts was seen. The gastrointestinal immune response thus plays a pivotal role in maintaining protective immunity in health and a critical role in the pathogenesis of a wide variety of clinical disorders associated with FA." @default.
• W2014651504 created "2016-06-24" @default.
• W2014651504 creator A5017081796 @default.
• W2014651504 creator A5017654551 @default.
• W2014651504 creator A5082390416 @default.
• W2014651504 date "2004-11-01" @default.
• W2014651504 modified "2023-10-18" @default.
• W2014651504 title "Gastrointestinal immunopathology and food allergy" @default.
• W2014651504 cites W1586678823 @default.
• W2014651504 cites W1777407783 @default.
• W2014651504 cites W1965327494 @default.
• W2014651504 cites W1969648891 @default.
• W2014651504 cites W1978945518 @default.
• W2014651504 cites W1989671941 @default.
• W2014651504 cites W1990227965 @default.
• W2014651504 cites W1998177146 @default.
• W2014651504 cites W2003111539 @default.
• W2014651504 cites W2016377527 @default.
• W2014651504 cites W2019028247 @default.
• W2014651504 cites W2022027267 @default.
• W2014651504 cites W2025616160 @default.
• W2014651504 cites W2032528146 @default.
• W2014651504 cites W2035525109 @default.
• W2014651504 cites W2037186592 @default.
• W2014651504 cites W2050733826 @default.
• W2014651504 cites W2075041765 @default.
• W2014651504 cites W2075376701 @default.
• W2014651504 cites W2083020827 @default.
• W2014651504 cites W2105047981 @default.
• W2014651504 cites W2137065746 @default.
• W2014651504 cites W2150151304 @default.
• W2014651504 cites W2161597539 @default.
• W2014651504 cites W2170797914 @default.
• W2014651504 doi "https://doi.org/10.1016/s1081-1206(10)61729-2" @default.
• W2014651504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15562871" @default.
• W2014651504 hasPublicationYear "2004" @default.
• W2014651504 type Work @default.
• W2014651504 sameAs 2014651504 @default.
• W2014651504 citedByCount "5" @default.
• W2014651504 countsByYear W20146515042017 @default.
• W2014651504 crossrefType "journal-article" @default.
• W2014651504 hasAuthorship W2014651504A5017081796 @default.
• W2014651504 hasAuthorship W2014651504A5017654551 @default.
• W2014651504 hasAuthorship W2014651504A5082390416 @default.
• W2014651504 hasConcept C137061746 @default.
• W2014651504 hasConcept C141105273 @default.
• W2014651504 hasConcept C142724271 @default.
• W2014651504 hasConcept C159654299 @default.
• W2014651504 hasConcept C167672396 @default.
• W2014651504 hasConcept C202751555 @default.
• W2014651504 hasConcept C203014093 @default.
• W2014651504 hasConcept C207480886 @default.
• W2014651504 hasConcept C2779134260 @default.
• W2014651504 hasConcept C2780648854 @default.
• W2014651504 hasConcept C2780942790 @default.
• W2014651504 hasConcept C55493867 @default.
• W2014651504 hasConcept C71924100 @default.
• W2014651504 hasConcept C86803240 @default.
• W2014651504 hasConcept C8891405 @default.
• W2014651504 hasConceptScore W2014651504C137061746 @default.
• W2014651504 hasConceptScore W2014651504C141105273 @default.
• W2014651504 hasConceptScore W2014651504C142724271 @default.
• W2014651504 hasConceptScore W2014651504C159654299 @default.
• W2014651504 hasConceptScore W2014651504C167672396 @default.
• W2014651504 hasConceptScore W2014651504C202751555 @default.
• W2014651504 hasConceptScore W2014651504C203014093 @default.
• W2014651504 hasConceptScore W2014651504C207480886 @default.
• W2014651504 hasConceptScore W2014651504C2779134260 @default.
• W2014651504 hasConceptScore W2014651504C2780648854 @default.
• W2014651504 hasConceptScore W2014651504C2780942790 @default.
• W2014651504 hasConceptScore W2014651504C55493867 @default.
• W2014651504 hasConceptScore W2014651504C71924100 @default.
• W2014651504 hasConceptScore W2014651504C86803240 @default.
• W2014651504 hasConceptScore W2014651504C8891405 @default.
• W2014651504 hasIssue "5" @default.
• W2014651504 hasLocation W20146515041 @default.
• W2014651504 hasLocation W20146515042 @default.
• W2014651504 hasOpenAccess W2014651504 @default.
• W2014651504 hasPrimaryLocation W20146515041 @default.
• W2014651504 hasRelatedWork W1988025298 @default.
• W2014651504 hasRelatedWork W2021413282 @default.
• W2014651504 hasRelatedWork W2024030696 @default.
• W2014651504 hasRelatedWork W2041967174 @default.
• W2014651504 hasRelatedWork W2050374169 @default.
• W2014651504 hasRelatedWork W2093870599 @default.
• W2014651504 hasRelatedWork W2129149137 @default.
• W2014651504 hasRelatedWork W2167755986 @default.
• W2014651504 hasRelatedWork W2394298848 @default.
• W2014651504 hasRelatedWork W5456082 @default.
• W2014651504 hasVolume "93" @default.
• W2014651504 isParatext "false" @default.
• W2014651504 isRetracted "false" @default.
• W2014651504 magId "2014651504" @default.
• W2014651504 workType "article" @default.