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- W2014652007 abstract "Testing the procoagulant activity (P.C.A.) of cerebrospinal fluid (C.S.F.) by measuring its effect on plasma-recalcification time is a useful indicator of central-nervous-system damage. C.S.F. from 22 normal children and adolescents aged 6 months to 17 years had a mean ±S.D. P.C.A. of 14±6%. P.C.A. in 13 children with C.N.S. infection was significantly increased to 59±13%. In 8/13 of these children activity remained high (42±11%) after therapy. In patients with acute lymphatic leukæmia (A.L.L.) 12 aged >21/2 years at diagnosis had a normal activity (17±8%) and 4 patients aged <21/2 years at diagnosis had an activity of 21±8%; during C.N.S. prophylaxis with intrathecal methotrexate and/or cranial irradiation, mean activity in these 16 patients rose significantly to 41±11%. More than 2 years after treatment P.C.A. decreased towards normal in the older children but remained high in the younger group. 5 children with neurological sequelæ (including 3 with A.L.L. and the post-irradiation syndrome) had the highest activities. Ether extraction showed that the active material had lipid properties. P.C.A. did not correlate with protein, lactic dehydrogenase, or cell count in C.S.F." @default.
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- W2014652007 date "1978-08-01" @default.
- W2014652007 modified "2023-09-27" @default.
- W2014652007 title "SPINAL-FLUID PROCOAGULANT ACTIVITY: A SENSITIVE INDICATOR OF CENTRAL-NERVOUS-SYSTEM DAMAGE" @default.
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- W2014652007 doi "https://doi.org/10.1016/s0140-6736(78)91689-6" @default.
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