FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014652373> ?p ?o ?g. }

• W2014652373 endingPage "1126" @default.
• W2014652373 startingPage "1117" @default.
• W2014652373 abstract "PSD-Zip45 (also named Homer 1c/Vesl-1L) is a synaptic scaffolding protein, which interacts with neurotransmitter receptors and other scaffolding proteins to target them into post-synaptic density (PSD), a specialized protein complex at the synaptic junction. Binding of the PSD-Zip45 to the receptors and scaffolding proteins results in colocalization and clustering of its binding partners in PSD. It has an Ena/VASP homology 1 (EVH1) domain in the N terminus for receptor binding, two leucine zipper motifs in the C terminus for clustering, and a linking region whose function is unclear despite the high level of conservation within the Homer 1 family. The X-ray crystallographic analysis of the largest fragment of residues 1-163, including an EVH1 domain reported here, demonstrates that the EVH1 domain contains an alpha-helix longer than that of the previous models, and that the linking part included in the conserved region of Homer 1 (CRH1) of the PSD-Zip45 interacts with the EVH1 domain of the neighbour CRH1 molecule in the crystal. The results suggest that the EVH1 domain recognizes the PPXXF motif found in the binding partners, and the SPLTP sequence (P-motif) in the linking region of the CRH1. The two types of binding are partly overlapped in the EVH1 domain, implying a mechanism to regulate multimerization of Homer 1 family proteins." @default.
• W2014652373 created "2016-06-24" @default.
• W2014652373 creator A5007145673 @default.
• W2014652373 creator A5022487976 @default.
• W2014652373 creator A5025207906 @default.
• W2014652373 creator A5026631659 @default.
• W2014652373 creator A5032548893 @default.
• W2014652373 creator A5043817262 @default.
• W2014652373 creator A5057464547 @default.
• W2014652373 creator A5064027488 @default.
• W2014652373 creator A5067709784 @default.
• W2014652373 date "2002-05-01" @default.
• W2014652373 modified "2023-09-24" @default.
• W2014652373 title "Crystal Structure of the Homer 1 Family Conserved Region Reveals the Interaction Between the EVH1 Domain and Own Proline-rich Motif" @default.
• W2014652373 cites W1520730837 @default.
• W2014652373 cites W1541120693 @default.
• W2014652373 cites W1586749300 @default.
• W2014652373 cites W1966761076 @default.
• W2014652373 cites W1969947371 @default.
• W2014652373 cites W1972183007 @default.
• W2014652373 cites W1982740419 @default.
• W2014652373 cites W1986191025 @default.
• W2014652373 cites W1993228567 @default.
• W2014652373 cites W1995017064 @default.
• W2014652373 cites W1995617887 @default.
• W2014652373 cites W2001641653 @default.
• W2014652373 cites W2001797086 @default.
• W2014652373 cites W2014187063 @default.
• W2014652373 cites W2017020850 @default.
• W2014652373 cites W2028231353 @default.
• W2014652373 cites W2038840577 @default.
• W2014652373 cites W2042651745 @default.
• W2014652373 cites W2054081721 @default.
• W2014652373 cites W2062904839 @default.
• W2014652373 cites W2075597274 @default.
• W2014652373 cites W2080476827 @default.
• W2014652373 cites W2080528351 @default.
• W2014652373 cites W2082600620 @default.
• W2014652373 cites W2095169963 @default.
• W2014652373 cites W2101873410 @default.
• W2014652373 cites W2103990201 @default.
• W2014652373 cites W2123395043 @default.
• W2014652373 cites W2130166312 @default.
• W2014652373 cites W2143478420 @default.
• W2014652373 cites W2153330341 @default.
• W2014652373 cites W2157715218 @default.
• W2014652373 cites W2164762131 @default.
• W2014652373 cites W290273672 @default.
• W2014652373 cites W4242482565 @default.
• W2014652373 cites W4245437574 @default.
• W2014652373 doi "https://doi.org/10.1016/s0022-2836(02)00170-5" @default.
• W2014652373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12054806" @default.
• W2014652373 hasPublicationYear "2002" @default.
• W2014652373 type Work @default.
• W2014652373 sameAs 2014652373 @default.
• W2014652373 citedByCount "31" @default.
• W2014652373 countsByYear W20146523732012 @default.
• W2014652373 countsByYear W20146523732014 @default.
• W2014652373 countsByYear W20146523732015 @default.
• W2014652373 countsByYear W20146523732018 @default.
• W2014652373 countsByYear W20146523732019 @default.
• W2014652373 countsByYear W20146523732020 @default.
• W2014652373 countsByYear W20146523732021 @default.
• W2014652373 crossrefType "journal-article" @default.
• W2014652373 hasAuthorship W2014652373A5007145673 @default.
• W2014652373 hasAuthorship W2014652373A5022487976 @default.
• W2014652373 hasAuthorship W2014652373A5025207906 @default.
• W2014652373 hasAuthorship W2014652373A5026631659 @default.
• W2014652373 hasAuthorship W2014652373A5032548893 @default.
• W2014652373 hasAuthorship W2014652373A5043817262 @default.
• W2014652373 hasAuthorship W2014652373A5057464547 @default.
• W2014652373 hasAuthorship W2014652373A5064027488 @default.
• W2014652373 hasAuthorship W2014652373A5067709784 @default.
• W2014652373 hasConcept C104317684 @default.
• W2014652373 hasConcept C12554922 @default.
• W2014652373 hasConcept C156860981 @default.
• W2014652373 hasConcept C167625842 @default.
• W2014652373 hasConcept C42086223 @default.
• W2014652373 hasConcept C53645450 @default.
• W2014652373 hasConcept C55493867 @default.
• W2014652373 hasConcept C62478195 @default.
• W2014652373 hasConcept C86803240 @default.
• W2014652373 hasConcept C95444343 @default.
• W2014652373 hasConceptScore W2014652373C104317684 @default.
• W2014652373 hasConceptScore W2014652373C12554922 @default.
• W2014652373 hasConceptScore W2014652373C156860981 @default.
• W2014652373 hasConceptScore W2014652373C167625842 @default.
• W2014652373 hasConceptScore W2014652373C42086223 @default.
• W2014652373 hasConceptScore W2014652373C53645450 @default.
• W2014652373 hasConceptScore W2014652373C55493867 @default.
• W2014652373 hasConceptScore W2014652373C62478195 @default.
• W2014652373 hasConceptScore W2014652373C86803240 @default.
• W2014652373 hasConceptScore W2014652373C95444343 @default.
• W2014652373 hasIssue "4" @default.
• W2014652373 hasLocation W20146523731 @default.
• W2014652373 hasLocation W20146523732 @default.
• W2014652373 hasOpenAccess W2014652373 @default.
• W2014652373 hasPrimaryLocation W20146523731 @default.

• next