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- W2014656720 abstract "The addition of clonidine to local anesthesia prolongs the local anesthetic action, but in humans, the contribution of a peripheral mechanism remains unclear.We investigated clonidine's peripheral effect in 20 healthy volunteers undergoing double-blind, subcutaneous infiltration of 0.5% lidocaine with normal saline to one forearm and then, immediately, of lidocaine with 10 mug clonidine to the contralateral arm. Pinprick sensation was tested every 15 min for 6 h.Median time to return of normal sensation was 3.5 h for lidocaine alone, but at least 6 h if combined with clonidine (P < 0.001).Clonidine has a significant peripheral action in enhancing duration of local anesthesia on superficial co-infiltration with lidocaine." @default.
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- W2014656720 date "2007-04-01" @default.
- W2014656720 modified "2023-09-28" @default.
- W2014656720 title "Co-injection of Clonidine Prolongs the Anesthetic Effect of Lidocaine Skin Infiltration by a Peripheral Action" @default.
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- W2014656720 doi "https://doi.org/10.1213/01.ane.0000257949.46444.a8" @default.
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