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• W2014660087 abstract "Abstract Aim: To identify differential patterns of brain activation between adolescents with bipolar disorder and adolescents with attention‐deficit hyperactivity disorder (ADHD) to better understand the neurophysiology of both disorders. We hypothesized that subjects with ADHD would show altered activation in brain regions involved in executive and sustained attention. In contrast, we hypothesized that bipolar subjects would show altered brain activation in regions responsible for emotionally homeostasis, including the striatum and amygdala. Methods: Functional magnetic resonance imaging was performed during a continuous performance task with a response inhibition component in 11 adolescents with bipolar disorder during a manic episode, 10 adolescents with ADHD, and 13 healthy adolescents. Results: There were no differences in behavioural performance among the three groups. Compared with bipolar subjects, subjects with ADHD showed increased activation in the superior temporal lobe during successful response inhibition. Although bipolar subjects did not show activation differences in the striatum or amygdala compared with ADHD subjects, increased left parahippocampal activation in the bipolar group was associated with increased manic symptoms. Conclusions: The patterns of brain activation observed in the current study support divergent patterns of neurophysiological dysfunction in individuals with bipolar disorder as compared with those with ADHD. Therefore, the impulsive behaviour seen in both disorders may be the consequence of dysfunction in different brain regions, and further research may help identify neurobiological markers that are specific to each condition." @default.
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• W2014660087 date "2009-08-01" @default.
• W2014660087 modified "2023-10-17" @default.
• W2014660087 title "Differential brain activation during response inhibition in bipolar and attention-deficit hyperactivity disorders" @default.
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• W2014660087 doi "https://doi.org/10.1111/j.1751-7893.2009.00132.x" @default.
• W2014660087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7032180" @default.
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