FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014665003> ?p ?o ?g. }

• W2014665003 endingPage "29" @default.
• W2014665003 startingPage "21" @default.
• W2014665003 abstract "Drosophila Crumbs is a transmembrane protein that plays an important role in epithelial cell polarity and photoreceptor development. Overexpression of Crumbs in Drosophila epithelia expands the apical surface and leads to disruption of cell polarity. Drosophila Crumbs also interacts with two other polarity genes, Stardust and Discs Lost. Recent work has identified a human orthologue of Drosophila Crumbs, known as CRB1, that is mutated in the eye disorders, retinitis pigmentosa and Leber congenital amaurosis. Our work has demonstrated that human CRB1 can form a complex with mammalian orthologues of Stardust and Discs Lost, known as protein associated with Lin-7 (Pals1) and Pals1 associated tight junction (PATJ), respectively. In the current report we have cloned a full length cDNA for a human paralogue of CRB1 called Crumbs3 (CRB3). In contrast to Drosophila Crumbs and CRB1, CRB3 has a very short extracellular domain but like these proteins it has a conserved intracellular domain that allows it to complex with Pals1 and PATJ. Mouse and human CRB3 have identical intracellular domains but divergent extracellular domains except for a conserved N-glycosylation site. CRB3 is localized to the apical surface and tight junctions but the conserved N linked glycosylation site does not appear to be necessary for CRB3 apical targeting. CRB3 is a specialized isoform of the Crumbs protein family that is expressed in epithelia and can tie the apical membrane to the tight junction." @default.
• W2014665003 created "2016-06-24" @default.
• W2014665003 creator A5039836090 @default.
• W2014665003 creator A5046728026 @default.
• W2014665003 creator A5061161189 @default.
• W2014665003 creator A5068110148 @default.
• W2014665003 creator A5077234538 @default.
• W2014665003 date "2003-01-01" @default.
• W2014665003 modified "2023-09-27" @default.
• W2014665003 title "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)" @default.
• W2014665003 cites W10039931 @default.
• W2014665003 cites W1966032423 @default.
• W2014665003 cites W1977284325 @default.
• W2014665003 cites W1987704449 @default.
• W2014665003 cites W2006249044 @default.
• W2014665003 cites W2012569825 @default.
• W2014665003 cites W2015889211 @default.
• W2014665003 cites W2026835299 @default.
• W2014665003 cites W2048529602 @default.
• W2014665003 cites W2054696788 @default.
• W2014665003 cites W2066562134 @default.
• W2014665003 cites W2067513535 @default.
• W2014665003 cites W2069455944 @default.
• W2014665003 cites W2077159019 @default.
• W2014665003 cites W2083609148 @default.
• W2014665003 cites W2090478518 @default.
• W2014665003 cites W2126582065 @default.
• W2014665003 cites W2133862855 @default.
• W2014665003 cites W2136032801 @default.
• W2014665003 cites W2143776806 @default.
• W2014665003 cites W2152770371 @default.
• W2014665003 cites W2154985199 @default.
• W2014665003 cites W2156874028 @default.
• W2014665003 cites W2165324125 @default.
• W2014665003 cites W2168572942 @default.
• W2014665003 cites W2171091522 @default.
• W2014665003 cites W2182359301 @default.
• W2014665003 doi "https://doi.org/10.1016/s0378111902010843" @default.
• W2014665003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12527193" @default.
• W2014665003 hasPublicationYear "2003" @default.
• W2014665003 type Work @default.
• W2014665003 sameAs 2014665003 @default.
• W2014665003 citedByCount "172" @default.
• W2014665003 countsByYear W20146650032012 @default.
• W2014665003 countsByYear W20146650032013 @default.
• W2014665003 countsByYear W20146650032014 @default.
• W2014665003 countsByYear W20146650032015 @default.
• W2014665003 countsByYear W20146650032016 @default.
• W2014665003 countsByYear W20146650032017 @default.
• W2014665003 countsByYear W20146650032018 @default.
• W2014665003 countsByYear W20146650032019 @default.
• W2014665003 countsByYear W20146650032020 @default.
• W2014665003 countsByYear W20146650032021 @default.
• W2014665003 countsByYear W20146650032022 @default.
• W2014665003 countsByYear W20146650032023 @default.
• W2014665003 crossrefType "journal-article" @default.
• W2014665003 hasAuthorship W2014665003A5039836090 @default.
• W2014665003 hasAuthorship W2014665003A5046728026 @default.
• W2014665003 hasAuthorship W2014665003A5061161189 @default.
• W2014665003 hasAuthorship W2014665003A5068110148 @default.
• W2014665003 hasAuthorship W2014665003A5077234538 @default.
• W2014665003 hasConcept C104317684 @default.
• W2014665003 hasConcept C118892022 @default.
• W2014665003 hasConcept C144647389 @default.
• W2014665003 hasConcept C1491633281 @default.
• W2014665003 hasConcept C170493617 @default.
• W2014665003 hasConcept C24530287 @default.
• W2014665003 hasConcept C2777361361 @default.
• W2014665003 hasConcept C3018436504 @default.
• W2014665003 hasConcept C39587587 @default.
• W2014665003 hasConcept C41625074 @default.
• W2014665003 hasConcept C49353375 @default.
• W2014665003 hasConcept C529295009 @default.
• W2014665003 hasConcept C54355233 @default.
• W2014665003 hasConcept C86803240 @default.
• W2014665003 hasConcept C95444343 @default.
• W2014665003 hasConceptScore W2014665003C104317684 @default.
• W2014665003 hasConceptScore W2014665003C118892022 @default.
• W2014665003 hasConceptScore W2014665003C144647389 @default.
• W2014665003 hasConceptScore W2014665003C1491633281 @default.
• W2014665003 hasConceptScore W2014665003C170493617 @default.
• W2014665003 hasConceptScore W2014665003C24530287 @default.
• W2014665003 hasConceptScore W2014665003C2777361361 @default.
• W2014665003 hasConceptScore W2014665003C3018436504 @default.
• W2014665003 hasConceptScore W2014665003C39587587 @default.
• W2014665003 hasConceptScore W2014665003C41625074 @default.
• W2014665003 hasConceptScore W2014665003C49353375 @default.
• W2014665003 hasConceptScore W2014665003C529295009 @default.
• W2014665003 hasConceptScore W2014665003C54355233 @default.
• W2014665003 hasConceptScore W2014665003C86803240 @default.
• W2014665003 hasConceptScore W2014665003C95444343 @default.
• W2014665003 hasIssue "1-2" @default.
• W2014665003 hasLocation W20146650031 @default.
• W2014665003 hasLocation W20146650032 @default.
• W2014665003 hasOpenAccess W2014665003 @default.
• W2014665003 hasPrimaryLocation W20146650031 @default.
• W2014665003 hasRelatedWork W1987971027 @default.
• W2014665003 hasRelatedWork W2027331638 @default.

• next