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• W2014665348 abstract "A series of aza analogues of the marine alkaloids wakayin and tsitsikammamines A and B have been synthesized. The strategy used was based on [3 + 2] cycloaddition reactions involving 3-ethylamine-indole-4,7-dione and different diazo reagents. All the compounds were evaluated in vitro for antiproliferative activity against five distinct cancer cell lines and for their inhibitory effect on topoisomerase isoenzymes I and II. Some of the compounds inhibited the topoisomerase I and/or II catalyzed relaxation of supercoiled DNA at a concentration comparable to the drugs camptothecin and etoposide. Only a few of them exhibited cytotoxic activity with IC50 values in the micromolar range." @default.
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• W2014665348 date "2006-04-25" @default.
• W2014665348 modified "2023-10-10" @default.
• W2014665348 title "Synthesis and Antitumor Characterization of Pyrazolic Analogues of the Marine Pyrroloquinoline Alkaloids: Wakayin and Tsitsikammamines" @default.
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• W2014665348 doi "https://doi.org/10.1021/jm051247f" @default.
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