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- W2014667964 abstract "• Monitoring of 5-hydroxyindole (5-HI) levels in blood in hyperactive institutionalized mentally retarded patients before and after drug therapy revealed depression of 5-HI levels in 83% of hyperactive patients. In these patients with low serotonin levels, elevation of 5-HI levels in blood into the normal range by administration of a variety of psychoactive agents was associated with the disappearance of the hyperkinetic syndrome. Patients who remained hyperactive continued to have low 5-HI levels. Return of hyperactivity upon withdrawal of medication in patients who were previously well controlled was associated with a fall in 5-HI levels. Adverse responses were seen in these patients when they were treated with medications usually tending to lower 5-HI levels in blood. Medications used in the treatment of hyperactivity may be classified as to whether they usually elevate, lower, or have no significant effect on 5-HI levels in blood." @default.
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- W2014667964 date "1976-03-01" @default.
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- W2014667964 title "Depressed 5-Hydroxyindole Levels Associated With Hyperactive and Aggressive Behavior" @default.
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- W2014667964 doi "https://doi.org/10.1001/archpsyc.1976.01770030045006" @default.
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