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• W2014671012 abstract "Acromegaly is associated with a significant increase in mortality resulting mainly from vascular disease, possibly due to growth hormone (GH) [ [1] Clayton R.N. Cardiovascular function in acromegaly. Endocr. Rev. 2003; 24: 272-277 Crossref PubMed Scopus (179) Google Scholar ]. Although cardiac alterations have been widely investigated in acromegaly [ 1 Clayton R.N. Cardiovascular function in acromegaly. Endocr. Rev. 2003; 24: 272-277 Crossref PubMed Scopus (179) Google Scholar , 2 Csanády M. Gáspár L. Hőgye M. Gruber N. The heart in acromegaly: an echocardiographic study. Int. J. Cardiol. 1983; 2: 349-361 Abstract Full Text PDF PubMed Scopus (32) Google Scholar ], vascular elasticity was rarely assessed [ 3 Smith J.C. Lane H. Davies N. Evans L.M. Cockcroft J. Scanlon M.F. et al. The effects of depot long-acting somatostatin analog on central aortic pressure and arterial stiffness in acromegaly. J. Clin. Endocrinol. Metab. 2003; 88: 2556-2561 Crossref PubMed Scopus (37) Google Scholar , 4 A. Nemes, H. Gavallér, É. Csajbók, J. Julesz, T. Forster, M. Csanády, Aortic stiffness is increased in acromegaly—a transthoracic echocardiographic study, Int. J. Cardiol., in press. Google Scholar ]. In recent studies, acromegaly was associated with changes in the central arterial pressure waveform [ [3] Smith J.C. Lane H. Davies N. Evans L.M. Cockcroft J. Scanlon M.F. et al. The effects of depot long-acting somatostatin analog on central aortic pressure and arterial stiffness in acromegaly. J. Clin. Endocrinol. Metab. 2003; 88: 2556-2561 Crossref PubMed Scopus (37) Google Scholar ] and increased aortic stiffness index [ [4] A. Nemes, H. Gavallér, É. Csajbók, J. Julesz, T. Forster, M. Csanády, Aortic stiffness is increased in acromegaly—a transthoracic echocardiographic study, Int. J. Cardiol., in press. Google Scholar ]. It is well documented that diabetes mellitus (DM) is associated with micro- and macrovascular complications [ [5] Nemes A. Forster T. Csanády M. Reduced aortic distensibility and coronary flow velocity reserve in diabetes mellitus patients with a negative coronary angiogram. Can. J. Cardiol. 2007; 23: 445-450 Abstract Full Text PDF PubMed Scopus (32) Google Scholar ]. Increased aortic stiffness has been reported in DM patients with negative coronary angiograms as compared to non-diabetic subjects, with data similar to those in non-diabetic patients with left anterior descending coronary artery stenosis [ [5] Nemes A. Forster T. Csanády M. Reduced aortic distensibility and coronary flow velocity reserve in diabetes mellitus patients with a negative coronary angiogram. Can. J. Cardiol. 2007; 23: 445-450 Abstract Full Text PDF PubMed Scopus (32) Google Scholar ]. The aim of this preliminary study was to examine the effect of DM on aortic elasticity in patients with acromegaly." @default.
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• W2014671012 title "Does diabetes mellitus facilitate aortic stiffening in acromegaly?" @default.
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