FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014673722> ?p ?o ?g. }

• W2014673722 endingPage "2666" @default.
• W2014673722 startingPage "2658" @default.
• W2014673722 abstract "Excess weight gain contributes up to 65% of the risk of primary hypertension, and the increase in blood pressure in response to high-fat diet (HFD) is preceded by significant increases in renal tubular sodium (Na+) reabsorption. In normal rats, intrarenal ghrelin infusion increases distal nephron-dependent Na+ reabsorption via activation of the intrarenal ghrelin receptor (GHSR). This study focusses on the role of intrarenal GHSR-mediated Na+ reabsorption in HFD-induced hypertension. Dahl salt-sensitive rats received standard diet or HFD for 6 weeks. Rats underwent uninephrectomy and osmotic minipump implantation for chronic intrarenal delivery of vehicle (0.25 μL/h × 28 d), selective GHSR antagonist [D-Lys-3]-growth hormone releasing peptide-6 (0.2μM/d), or GHSR inverse agonist [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P (SUB-P) (3.6μM/d). HFD rats with vehicle pumps had significantly increased renal GHSR expression compared with standard diet (0.092 ± 0.005 vs 0.065 ± 0.004 arbitrary units; P &lt; .05), whereas acyl ghrelin levels were similar (16.3±6.2 vs 15.7±8.7 pg/g tissue). HFD rats with vehicle pumps became hypertensive after 2 weeks (P &lt; .05) and showed a significant reduction in 24-hour urine Na+ before hypertension. At this time, these rats showed an increase in collecting duct α-epithelial Na+ channel, thereby providing a potential mechanism for the excess Na+ reabsorption. In contrast, HFD rats with [D-Lys-3]-growth hormone releasing peptide-6 or SUB-P pumps never became hypertensive and did not show the reduction in urine Na+. Because SUB-P blocks the constitutive, but not ghrelin-dependent, activity of the GHSR, and HFD-induced α-epithelial Na+ channel up-regulation was abolished during GHSR antagonism, these data suggest that HFD increases the constitutive activity of renal GHSR to increase Na+ reabsorption and induce hypertension in rats." @default.
• W2014673722 created "2016-06-24" @default.
• W2014673722 creator A5020463389 @default.
• W2014673722 creator A5035507006 @default.
• W2014673722 creator A5083006928 @default.
• W2014673722 creator A5091055627 @default.
• W2014673722 date "2014-07-01" @default.
• W2014673722 modified "2023-09-25" @default.
• W2014673722 title "Intrarenal Ghrelin Receptor Antagonism Prevents High-Fat Diet-Induced Hypertension in Male Rats" @default.
• W2014673722 cites W1901716085 @default.
• W2014673722 cites W1968647081 @default.
• W2014673722 cites W1970224180 @default.
• W2014673722 cites W1971036356 @default.
• W2014673722 cites W1980454628 @default.
• W2014673722 cites W1982416171 @default.
• W2014673722 cites W1984097105 @default.
• W2014673722 cites W1988796963 @default.
• W2014673722 cites W1990155504 @default.
• W2014673722 cites W2001755357 @default.
• W2014673722 cites W2007642910 @default.
• W2014673722 cites W2013332206 @default.
• W2014673722 cites W2029490049 @default.
• W2014673722 cites W2046772630 @default.
• W2014673722 cites W2048986390 @default.
• W2014673722 cites W2060736398 @default.
• W2014673722 cites W2066247992 @default.
• W2014673722 cites W2085372550 @default.
• W2014673722 cites W2086351950 @default.
• W2014673722 cites W2088112872 @default.
• W2014673722 cites W2095606723 @default.
• W2014673722 cites W2105573142 @default.
• W2014673722 cites W2106784014 @default.
• W2014673722 cites W2114922768 @default.
• W2014673722 cites W2115944029 @default.
• W2014673722 cites W2123800764 @default.
• W2014673722 cites W2125280221 @default.
• W2014673722 cites W2129390727 @default.
• W2014673722 cites W2132485744 @default.
• W2014673722 cites W2141979154 @default.
• W2014673722 cites W2142532630 @default.
• W2014673722 cites W2148751725 @default.
• W2014673722 cites W2151002056 @default.
• W2014673722 cites W2159933178 @default.
• W2014673722 cites W2162085427 @default.
• W2014673722 cites W2162943132 @default.
• W2014673722 cites W2163094564 @default.
• W2014673722 cites W2168601664 @default.
• W2014673722 cites W2168988227 @default.
• W2014673722 cites W2314707437 @default.
• W2014673722 cites W2467042522 @default.
• W2014673722 doi "https://doi.org/10.1210/en.2013-2177" @default.
• W2014673722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24797629" @default.
• W2014673722 hasPublicationYear "2014" @default.
• W2014673722 type Work @default.
• W2014673722 sameAs 2014673722 @default.
• W2014673722 citedByCount "9" @default.
• W2014673722 countsByYear W20146737222015 @default.
• W2014673722 countsByYear W20146737222018 @default.
• W2014673722 countsByYear W20146737222019 @default.
• W2014673722 countsByYear W20146737222020 @default.
• W2014673722 countsByYear W20146737222022 @default.
• W2014673722 crossrefType "journal-article" @default.
• W2014673722 hasAuthorship W2014673722A5020463389 @default.
• W2014673722 hasAuthorship W2014673722A5035507006 @default.
• W2014673722 hasAuthorship W2014673722A5083006928 @default.
• W2014673722 hasAuthorship W2014673722A5091055627 @default.
• W2014673722 hasBestOaLocation W20146737221 @default.
• W2014673722 hasConcept C126322002 @default.
• W2014673722 hasConcept C134018914 @default.
• W2014673722 hasConcept C170493617 @default.
• W2014673722 hasConcept C185592680 @default.
• W2014673722 hasConcept C2778938600 @default.
• W2014673722 hasConcept C2779357093 @default.
• W2014673722 hasConcept C2780091579 @default.
• W2014673722 hasConcept C2781231759 @default.
• W2014673722 hasConcept C56906281 @default.
• W2014673722 hasConcept C71315377 @default.
• W2014673722 hasConcept C71924100 @default.
• W2014673722 hasConcept C86803240 @default.
• W2014673722 hasConceptScore W2014673722C126322002 @default.
• W2014673722 hasConceptScore W2014673722C134018914 @default.
• W2014673722 hasConceptScore W2014673722C170493617 @default.
• W2014673722 hasConceptScore W2014673722C185592680 @default.
• W2014673722 hasConceptScore W2014673722C2778938600 @default.
• W2014673722 hasConceptScore W2014673722C2779357093 @default.
• W2014673722 hasConceptScore W2014673722C2780091579 @default.
• W2014673722 hasConceptScore W2014673722C2781231759 @default.
• W2014673722 hasConceptScore W2014673722C56906281 @default.
• W2014673722 hasConceptScore W2014673722C71315377 @default.
• W2014673722 hasConceptScore W2014673722C71924100 @default.
• W2014673722 hasConceptScore W2014673722C86803240 @default.
• W2014673722 hasIssue "7" @default.
• W2014673722 hasLocation W20146737221 @default.
• W2014673722 hasLocation W20146737222 @default.
• W2014673722 hasOpenAccess W2014673722 @default.
• W2014673722 hasPrimaryLocation W20146737221 @default.
• W2014673722 hasRelatedWork W1924012380 @default.
• W2014673722 hasRelatedWork W1984193137 @default.

• next