FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014676102> ?p ?o ?g. }

• W2014676102 endingPage "316" @default.
• W2014676102 startingPage "313" @default.
• W2014676102 abstract "“Industrial-strength doses” of niacin have been used safely for years for the treatment of hyperlipidemia,la2 and have been associated with reduced risk of coronary artery disease in primary and secondary prevention trials.3-6 Recently, there has been renewed interest in the use of niacin for lipid-lowering therapy. Several excellent articles that highlight its efficacy as well as its toxicity have been published within the past year.7-g It is curious that we have been “sold a bill of goods” about the benefits of modified-release niacin over unmodified niacin (regular, crystalline), when the medical literature clearly indicates that such preparations are only slightly less likely to be associated with the adverse skin effects and more likely to be associated with gastrointestinal complaints and abnormal liver function.7J0~11 These studies confirm that the unmodified forms of niacin are as well or better tolerated and less likely to be associated with adverse effects than the modified-release preparations, and that adverse effects are dose-related for both types of preparations. The literature suggests that approximately 50% to 75% of patients can tolerate niacin, particularly if reasonable doses are used.7-g,‘2 Modified-release preparations should probably never be used in excess of 2,000 mg/d, while the doses of unmodified niacin are more flexible; some patients can safely take very high doses.gr13-15 It may be reasonable for most primary care physicians to limit their prescription of unmodified niacin to 13,000 mg/d, and of slow-release preparations to 1,500-2,000 mg/d, and to refer resistant or difficult patients to lipid experts for treatment. There appear to be both dose-response and preparation-dependent relationships of niacin to changes in low-density lipoprotein cholesterol (LDLC), triglyceride, and high-density lipoprotein cholesterol (HDL-C) levels.7 The unmodified forms of niacin are better for increasing the HDL-C, and the modified-release preparations are better for decreasing the triglyceride levels; the two preparations appear to be equipotent at decreasing the LDL-C levels. Thus, the initial lipid pattern, as well as the goal(s) of therapy could serve to determine the dose, and perhaps the preparation, that is selected." @default.
• W2014676102 created "2016-06-24" @default.
• W2014676102 creator A5003623773 @default.
• W2014676102 date "1994-10-01" @default.
• W2014676102 modified "2023-10-04" @default.
• W2014676102 title "Niacin: A therapeutic dilemma “one man's drink is another's poison”" @default.
• W2014676102 cites W1968305164 @default.
• W2014676102 cites W1979102029 @default.
• W2014676102 cites W1988179941 @default.
• W2014676102 cites W2000921060 @default.
• W2014676102 cites W2001923460 @default.
• W2014676102 cites W2003636496 @default.
• W2014676102 cites W2005870798 @default.
• W2014676102 cites W2010047125 @default.
• W2014676102 cites W2012424714 @default.
• W2014676102 cites W2014010542 @default.
• W2014676102 cites W2029833995 @default.
• W2014676102 cites W2033321161 @default.
• W2014676102 cites W2044397157 @default.
• W2014676102 cites W2052048264 @default.
• W2014676102 cites W2061716149 @default.
• W2014676102 cites W2070855777 @default.
• W2014676102 cites W2074096468 @default.
• W2014676102 cites W2079818796 @default.
• W2014676102 cites W2088859305 @default.
• W2014676102 cites W2089648098 @default.
• W2014676102 cites W2092138949 @default.
• W2014676102 cites W2094172628 @default.
• W2014676102 cites W2095476831 @default.
• W2014676102 cites W2095885613 @default.
• W2014676102 cites W2115572248 @default.
• W2014676102 cites W2118310760 @default.
• W2014676102 cites W2124892367 @default.
• W2014676102 cites W2170750385 @default.
• W2014676102 cites W2324712847 @default.
• W2014676102 cites W4249750268 @default.
• W2014676102 cites W4299584139 @default.
• W2014676102 doi "https://doi.org/10.1016/0002-9343(94)90296-8" @default.
• W2014676102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7942931" @default.
• W2014676102 hasPublicationYear "1994" @default.
• W2014676102 type Work @default.
• W2014676102 sameAs 2014676102 @default.
• W2014676102 citedByCount "3" @default.
• W2014676102 crossrefType "journal-article" @default.
• W2014676102 hasAuthorship W2014676102A5003623773 @default.
• W2014676102 hasConcept C111472728 @default.
• W2014676102 hasConcept C126322002 @default.
• W2014676102 hasConcept C138885662 @default.
• W2014676102 hasConcept C2778496695 @default.
• W2014676102 hasConcept C2780092750 @default.
• W2014676102 hasConcept C3017944768 @default.
• W2014676102 hasConcept C526869908 @default.
• W2014676102 hasConcept C545542383 @default.
• W2014676102 hasConcept C71924100 @default.
• W2014676102 hasConceptScore W2014676102C111472728 @default.
• W2014676102 hasConceptScore W2014676102C126322002 @default.
• W2014676102 hasConceptScore W2014676102C138885662 @default.
• W2014676102 hasConceptScore W2014676102C2778496695 @default.
• W2014676102 hasConceptScore W2014676102C2780092750 @default.
• W2014676102 hasConceptScore W2014676102C3017944768 @default.
• W2014676102 hasConceptScore W2014676102C526869908 @default.
• W2014676102 hasConceptScore W2014676102C545542383 @default.
• W2014676102 hasConceptScore W2014676102C71924100 @default.
• W2014676102 hasIssue "4" @default.
• W2014676102 hasLocation W20146761021 @default.
• W2014676102 hasLocation W20146761022 @default.
• W2014676102 hasOpenAccess W2014676102 @default.
• W2014676102 hasPrimaryLocation W20146761021 @default.
• W2014676102 hasRelatedWork W1676168016 @default.
• W2014676102 hasRelatedWork W1966493942 @default.
• W2014676102 hasRelatedWork W1967302349 @default.
• W2014676102 hasRelatedWork W1991269480 @default.
• W2014676102 hasRelatedWork W2237087163 @default.
• W2014676102 hasRelatedWork W2253700937 @default.
• W2014676102 hasRelatedWork W2282580697 @default.
• W2014676102 hasRelatedWork W4242352147 @default.
• W2014676102 hasRelatedWork W4246489344 @default.
• W2014676102 hasRelatedWork W4249004872 @default.
• W2014676102 hasVolume "97" @default.
• W2014676102 isParatext "false" @default.
• W2014676102 isRetracted "false" @default.
• W2014676102 magId "2014676102" @default.
• W2014676102 workType "article" @default.