Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014677958> ?p ?o ?g. }
- W2014677958 endingPage "3601" @default.
- W2014677958 startingPage "3597" @default.
- W2014677958 abstract "Collagen is the most abundant protein in animals. Its prevalent 4-hydroxyproline residues contribute greatly to its conformational stability. The hydroxyl groups arise from a post-translational modification catalyzed by the nonheme iron-dependent enzyme, collagen prolyl 4-hydroxylase (P4H). Here, we report that 4-oxo-5,6-epoxyhexanoate, a mimic of the α-ketoglutarate co-substrate, inactivates human P4H. The inactivation installs a ketone functionality in P4H, providing a handle for proteomic experiments. Caenorhabditis elegans exposed to the esterified epoxy ketone displays the phenotype of a worm lacking P4H. Thus, this affinity label can be used to mediate collagen stability in an animal, as is desirable in the treatment of a variety of fibrotic diseases." @default.
- W2014677958 created "2016-06-24" @default.
- W2014677958 creator A5019213891 @default.
- W2014677958 creator A5019845986 @default.
- W2014677958 creator A5065359850 @default.
- W2014677958 creator A5079468232 @default.
- W2014677958 date "2013-06-01" @default.
- W2014677958 modified "2023-09-27" @default.
- W2014677958 title "Bioavailable affinity label for collagen prolyl 4-hydroxylase" @default.
- W2014677958 cites W1550877969 @default.
- W2014677958 cites W1974049559 @default.
- W2014677958 cites W1975070474 @default.
- W2014677958 cites W1976547599 @default.
- W2014677958 cites W1988377666 @default.
- W2014677958 cites W1992002958 @default.
- W2014677958 cites W1994313430 @default.
- W2014677958 cites W1994433728 @default.
- W2014677958 cites W1999197334 @default.
- W2014677958 cites W2003292237 @default.
- W2014677958 cites W2010621614 @default.
- W2014677958 cites W2014289051 @default.
- W2014677958 cites W2014965069 @default.
- W2014677958 cites W2026227369 @default.
- W2014677958 cites W2026272867 @default.
- W2014677958 cites W2033047468 @default.
- W2014677958 cites W2039794143 @default.
- W2014677958 cites W2047969741 @default.
- W2014677958 cites W2057080560 @default.
- W2014677958 cites W2066263439 @default.
- W2014677958 cites W2066386952 @default.
- W2014677958 cites W2069597443 @default.
- W2014677958 cites W2078825950 @default.
- W2014677958 cites W2080304171 @default.
- W2014677958 cites W2090870018 @default.
- W2014677958 cites W2098427962 @default.
- W2014677958 cites W2112278121 @default.
- W2014677958 cites W2149117196 @default.
- W2014677958 cites W2149554987 @default.
- W2014677958 cites W2161162374 @default.
- W2014677958 cites W2166179062 @default.
- W2014677958 cites W2166472612 @default.
- W2014677958 cites W2953249900 @default.
- W2014677958 doi "https://doi.org/10.1016/j.bmc.2013.04.057" @default.
- W2014677958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3723383" @default.
- W2014677958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23702396" @default.
- W2014677958 hasPublicationYear "2013" @default.
- W2014677958 type Work @default.
- W2014677958 sameAs 2014677958 @default.
- W2014677958 citedByCount "7" @default.
- W2014677958 countsByYear W20146779582015 @default.
- W2014677958 countsByYear W20146779582016 @default.
- W2014677958 countsByYear W20146779582018 @default.
- W2014677958 countsByYear W20146779582019 @default.
- W2014677958 countsByYear W20146779582020 @default.
- W2014677958 countsByYear W20146779582023 @default.
- W2014677958 crossrefType "journal-article" @default.
- W2014677958 hasAuthorship W2014677958A5019213891 @default.
- W2014677958 hasAuthorship W2014677958A5019845986 @default.
- W2014677958 hasAuthorship W2014677958A5065359850 @default.
- W2014677958 hasAuthorship W2014677958A5079468232 @default.
- W2014677958 hasBestOaLocation W20146779582 @default.
- W2014677958 hasConcept C104317684 @default.
- W2014677958 hasConcept C178790620 @default.
- W2014677958 hasConcept C181199279 @default.
- W2014677958 hasConcept C185592680 @default.
- W2014677958 hasConcept C18903297 @default.
- W2014677958 hasConcept C2777289219 @default.
- W2014677958 hasConcept C2777738585 @default.
- W2014677958 hasConcept C2778944004 @default.
- W2014677958 hasConcept C2779797417 @default.
- W2014677958 hasConcept C2781109383 @default.
- W2014677958 hasConcept C55493867 @default.
- W2014677958 hasConcept C71240020 @default.
- W2014677958 hasConcept C86803240 @default.
- W2014677958 hasConceptScore W2014677958C104317684 @default.
- W2014677958 hasConceptScore W2014677958C178790620 @default.
- W2014677958 hasConceptScore W2014677958C181199279 @default.
- W2014677958 hasConceptScore W2014677958C185592680 @default.
- W2014677958 hasConceptScore W2014677958C18903297 @default.
- W2014677958 hasConceptScore W2014677958C2777289219 @default.
- W2014677958 hasConceptScore W2014677958C2777738585 @default.
- W2014677958 hasConceptScore W2014677958C2778944004 @default.
- W2014677958 hasConceptScore W2014677958C2779797417 @default.
- W2014677958 hasConceptScore W2014677958C2781109383 @default.
- W2014677958 hasConceptScore W2014677958C55493867 @default.
- W2014677958 hasConceptScore W2014677958C71240020 @default.
- W2014677958 hasConceptScore W2014677958C86803240 @default.
- W2014677958 hasIssue "12" @default.
- W2014677958 hasLocation W20146779581 @default.
- W2014677958 hasLocation W20146779582 @default.
- W2014677958 hasLocation W20146779583 @default.
- W2014677958 hasLocation W20146779584 @default.
- W2014677958 hasOpenAccess W2014677958 @default.
- W2014677958 hasPrimaryLocation W20146779581 @default.
- W2014677958 hasRelatedWork W1966418295 @default.
- W2014677958 hasRelatedWork W1968657172 @default.
- W2014677958 hasRelatedWork W2014677958 @default.
- W2014677958 hasRelatedWork W2033694893 @default.