FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014680839> ?p ?o ?g. }

• W2014680839 endingPage "26" @default.
• W2014680839 startingPage "19" @default.
• W2014680839 abstract "Chronic renal failure (CRF) is frequently accompanied by systemic vascular alterations which further increase the morbidity and mortality of these patients. However, the nature and the underlying mechanisms of vascular dysfunction are not completely understood. We hypothesized that--in addition to other factors--CRF alters local vasomotor mechanisms that are intrinsic to the vascular wall.Changes in the diameter of isolated, pressurized (at 80 mm Hg) gracilis skeletal muscle arterioles (diameter approximately 150 microm) of female Wistar rats were investigated by videomicroscopy. Arteriolar responses to an increase in flow and vasoactive agents in partially nephrectomized (NX) and sham-operated (control) rats were compared.In NX rats, serum creatinine and urine protein excretion were increased. Compared to controls, increases in intraluminal flow (from 0 to 40 microl/min) resulted in significantly reduced dilation in arterioles of NX rats (maximum: 32 +/- 4 vs. 15 +/- 4 microm, p < 0.05). Inhibition of nitric oxide (NO) synthesis with L-NAME reduced the dilation of control arterioles but did not affect responses of NX arterioles. Also, dilations in response to histamine were significantly reduced in arterioles from NX rats as compared to control rats. L-NAME significantly decreased histamine-induced dilations of control arterioles, but it did not affect responses of NX arterioles. Dilations in response to the NO donor sodium nitroprusside were also significantly decreased in NX arterioles as compared to responses of control vessels, whereas responses to adenosine and norepinephrine were not significantly different in the two groups.We conclude that in rat skeletal muscle arterioles, CRF induced by renal mass reduction alters the mechanosensitive and agonist-induced responses of peripheral arterioles, in part by interfering with NO-signaling mechanisms. These alterations could contribute to increased peripheral vascular resistance and further aggravate the cardiovascular complications in CRF." @default.
• W2014680839 created "2016-06-24" @default.
• W2014680839 creator A5015124366 @default.
• W2014680839 creator A5023805075 @default.
• W2014680839 creator A5077912586 @default.
• W2014680839 creator A5079625728 @default.
• W2014680839 creator A5091606877 @default.
• W2014680839 date "2003-01-01" @default.
• W2014680839 modified "2023-10-18" @default.
• W2014680839 title "Chronic Renal Failure Leads to Reduced Flow-Dependent Dilation in Isolated Rat Skeletal Muscle Arterioles due to Lack of NO Mediation" @default.
• W2014680839 cites W1239392943 @default.
• W2014680839 cites W1965357313 @default.
• W2014680839 cites W1978001365 @default.
• W2014680839 cites W1983363332 @default.
• W2014680839 cites W1999041019 @default.
• W2014680839 cites W2027438662 @default.
• W2014680839 cites W2029911061 @default.
• W2014680839 cites W2032626829 @default.
• W2014680839 cites W2042592263 @default.
• W2014680839 cites W2051914522 @default.
• W2014680839 cites W2074675717 @default.
• W2014680839 cites W2076750400 @default.
• W2014680839 cites W2109576876 @default.
• W2014680839 cites W2124120174 @default.
• W2014680839 cites W2130963077 @default.
• W2014680839 cites W2133872346 @default.
• W2014680839 cites W2160205440 @default.
• W2014680839 cites W2170919931 @default.
• W2014680839 cites W2182743806 @default.
• W2014680839 cites W22521378 @default.
• W2014680839 cites W2281167093 @default.
• W2014680839 cites W2300787713 @default.
• W2014680839 cites W2315390590 @default.
• W2014680839 cites W2323589684 @default.
• W2014680839 cites W2404676277 @default.
• W2014680839 cites W2408102803 @default.
• W2014680839 cites W2421817919 @default.
• W2014680839 cites W2520733964 @default.
• W2014680839 cites W3026822981 @default.
• W2014680839 cites W994176246 @default.
• W2014680839 cites W2092159168 @default.
• W2014680839 doi "https://doi.org/10.1159/000069762" @default.
• W2014680839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12697973" @default.
• W2014680839 hasPublicationYear "2003" @default.
• W2014680839 type Work @default.
• W2014680839 sameAs 2014680839 @default.
• W2014680839 citedByCount "12" @default.
• W2014680839 countsByYear W20146808392012 @default.
• W2014680839 countsByYear W20146808392013 @default.
• W2014680839 countsByYear W20146808392020 @default.
• W2014680839 crossrefType "journal-article" @default.
• W2014680839 hasAuthorship W2014680839A5015124366 @default.
• W2014680839 hasAuthorship W2014680839A5023805075 @default.
• W2014680839 hasAuthorship W2014680839A5077912586 @default.
• W2014680839 hasAuthorship W2014680839A5079625728 @default.
• W2014680839 hasAuthorship W2014680839A5091606877 @default.
• W2014680839 hasConcept C1122143 @default.
• W2014680839 hasConcept C120770815 @default.
• W2014680839 hasConcept C126322002 @default.
• W2014680839 hasConcept C12722491 @default.
• W2014680839 hasConcept C134018914 @default.
• W2014680839 hasConcept C185592680 @default.
• W2014680839 hasConcept C2776214587 @default.
• W2014680839 hasConcept C2776952824 @default.
• W2014680839 hasConcept C2776991684 @default.
• W2014680839 hasConcept C2777032099 @default.
• W2014680839 hasConcept C2779395532 @default.
• W2014680839 hasConcept C2779482390 @default.
• W2014680839 hasConcept C2779610285 @default.
• W2014680839 hasConcept C2779959927 @default.
• W2014680839 hasConcept C2780091579 @default.
• W2014680839 hasConcept C2992686903 @default.
• W2014680839 hasConcept C519581460 @default.
• W2014680839 hasConcept C58336856 @default.
• W2014680839 hasConcept C71924100 @default.
• W2014680839 hasConcept C7643261 @default.
• W2014680839 hasConceptScore W2014680839C1122143 @default.
• W2014680839 hasConceptScore W2014680839C120770815 @default.
• W2014680839 hasConceptScore W2014680839C126322002 @default.
• W2014680839 hasConceptScore W2014680839C12722491 @default.
• W2014680839 hasConceptScore W2014680839C134018914 @default.
• W2014680839 hasConceptScore W2014680839C185592680 @default.
• W2014680839 hasConceptScore W2014680839C2776214587 @default.
• W2014680839 hasConceptScore W2014680839C2776952824 @default.
• W2014680839 hasConceptScore W2014680839C2776991684 @default.
• W2014680839 hasConceptScore W2014680839C2777032099 @default.
• W2014680839 hasConceptScore W2014680839C2779395532 @default.
• W2014680839 hasConceptScore W2014680839C2779482390 @default.
• W2014680839 hasConceptScore W2014680839C2779610285 @default.
• W2014680839 hasConceptScore W2014680839C2779959927 @default.
• W2014680839 hasConceptScore W2014680839C2780091579 @default.
• W2014680839 hasConceptScore W2014680839C2992686903 @default.
• W2014680839 hasConceptScore W2014680839C519581460 @default.
• W2014680839 hasConceptScore W2014680839C58336856 @default.
• W2014680839 hasConceptScore W2014680839C71924100 @default.
• W2014680839 hasConceptScore W2014680839C7643261 @default.
• W2014680839 hasIssue "1" @default.
• W2014680839 hasLocation W20146808391 @default.

• next