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- W2014682283 abstract "Eosinophils generate and store a battery of proteins, including classical cationic proteins, cytokines, chemokines, and growth factors. Rapid secretion of these active mediators by eosinophils is central to a range of inflammatory and immunoregulatory responses. Eosinophil products are packaged within a dominant population of cytoplasmic specific granules and generally secreted by piecemeal degranulation, a process mediated by transport vesicles. Large, pleiomorphic vesiculotubular carriers were identified recently as key players for moving eosinophil proteins from granules to the plasma membrane for extracellular release. During secretion, these specialized, morphologically distinct carriers, termed eosinophil sombrero vesicles, are actively formed and direct differential and rapid release of eosinophil proteins. This review highlights recent discoveries concerning the organization of the human eosinophil secretory pathway. These discoveries are defining a broader role for large vesiculotubular carriers in the intracellular trafficking and secretion of proteins, including selective receptor-mediated mobilization and transport of cytokines." @default.
- W2014682283 created "2016-06-24" @default.
- W2014682283 creator A5021692059 @default.
- W2014682283 creator A5022885245 @default.
- W2014682283 creator A5057608101 @default.
- W2014682283 creator A5059154238 @default.
- W2014682283 date "2007-09-17" @default.
- W2014682283 modified "2023-10-17" @default.
- W2014682283 title "Mechanisms of eosinophil secretion: large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins" @default.
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- W2014682283 doi "https://doi.org/10.1189/jlb.0707503" @default.
- W2014682283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2734949" @default.
- W2014682283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17875811" @default.
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