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• W2014684895 abstract "Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems.The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users." @default.
• W2014684895 created "2016-06-24" @default.
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• W2014684895 date "2010-05-09" @default.
• W2014684895 modified "2023-10-17" @default.
• W2014684895 title "Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems" @default.
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• W2014684895 doi "https://doi.org/10.1007/s11689-010-9049-0" @default.
• W2014684895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2930796" @default.
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