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- W2014688047 abstract "Using isolated rat islets of Langerhans perifused invitro, the differential effect of alpha- and beta-D-glucose on the protection against alloxan toxicity was studied in terms of subsequent glucose-induced insulin secretion. Alpha-D-glucose (5,3 and 1.5 mg/ml) produced similar protection to that by a corresponding concentration of equilibrated D-glucose, and was significantly greater than that by beta-D-glucose. There was no apparent protection against alloxan toxicity by a 1 mg/ml medium of either equilibrated D-glucose or beta-D-glucose. However, the addition of 1 mg/ml of alpha-D-glucose to the alloxan solution provided the islets with partial but distinct insulin secretion. These results indicate that stereospecificity plays a role in protection of the is lets against alloxan toxicity at the beta cell membrane. The stereospecificity of alpha-D-glucose appears greater for an alloxan site than for an insulin triggering site." @default.
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- W2014688047 title "Differential effect of alpha- and beta-D-glucose on protection against alloxan toxicity in isolated islets" @default.
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- W2014688047 doi "https://doi.org/10.1016/0006-291x(76)90879-2" @default.
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