FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014689871> ?p ?o ?g. }

• W2014689871 endingPage "99" @default.
• W2014689871 startingPage "95" @default.
• W2014689871 abstract "1. At present, CO2 is considered to be the most important factor in regulating cerebral blood flow by modification of the interstitial fluid and extracellular pH, but the mechanism by which hypercapnia produces vasodilation is still controversial. In the present paper we investigated the effect of hypercapnia on carbonic anhydrase (CA) activity. We also studied the combined effects of CO2 with either indomethacin or an L-arginine analogue on CA activity. 2. Nine groups of 12 rabbits each were established. Groups 1-4 were ventilated with a mixture of 10% CO2, 21% O2 and 69% N2 for 20, 60, 120 and 180 min. Group 5 rabbits received 15 mg/kg bodyweight, i.v., indomethacin and, after 1 h, were ventilated with a mixture of 10% CO2, 21% O2 and 69% N2 for 2 h. Group 6 animals were ventilated with a mixture of 10% CO2, 21% O2 and 69% N2 for 2 h and then received indomethacin. Group 7 rabbits received 100 mg/kg bodyweight, i.v., NG-monomethyl-L-arginine (L-NMMA) and, after 1 h, were ventilated with a mixture of 10% CO2, 21% O2 and 69% N2 for 2 h. Group 8 rabbits were ventilated for 2 h with a mixture of 10% CO2, 21% O2 and 69% N2 and were then administered L-NMMA. Group 9 rabbits received L-NMMA treatment concomitant with ventilation for 2 h with a mixture of 10% CO2, 21% O2 and 69% N2. In all groups, the erythrocyte CA activity was measured, as well as PaCO2 before and after ventilation or treatment. 3. The present study shows that CO2 reduces CA I activity down to complete inhibition and antagonizes the activating effects of indomethacin and L-NMMA on this isozyme. Our data prove that nitric oxide- and prostaglandin-induced CA I inhibition is involved in the vasodilation produced by hypercapnia. These results suggest that, due to subsequent pH changes, CA I is directly implicated in the modulation of vascular processes in the organism." @default.
• W2014689871 created "2016-06-24" @default.
• W2014689871 creator A5023550849 @default.
• W2014689871 creator A5032077820 @default.
• W2014689871 creator A5033822620 @default.
• W2014689871 creator A5042448049 @default.
• W2014689871 creator A5048010894 @default.
• W2014689871 creator A5073458173 @default.
• W2014689871 date "2000-01-04" @default.
• W2014689871 modified "2023-10-18" @default.
• W2014689871 title "Carbonic Anhydrase I Inhibition By Nitric Oxide: Implications For Mediation Of The Hypercapnia‐Induced Vasodilator Response" @default.
• W2014689871 cites W1573899446 @default.
• W2014689871 cites W1602635229 @default.
• W2014689871 cites W1804406719 @default.
• W2014689871 cites W1946153048 @default.
• W2014689871 cites W1964215363 @default.
• W2014689871 cites W1964653293 @default.
• W2014689871 cites W1991540962 @default.
• W2014689871 cites W1992002725 @default.
• W2014689871 cites W1994490479 @default.
• W2014689871 cites W1994649286 @default.
• W2014689871 cites W1994718318 @default.
• W2014689871 cites W2003528204 @default.
• W2014689871 cites W2025680091 @default.
• W2014689871 cites W2028527041 @default.
• W2014689871 cites W2029845554 @default.
• W2014689871 cites W2044062385 @default.
• W2014689871 cites W2045566200 @default.
• W2014689871 cites W2049768905 @default.
• W2014689871 cites W2052218174 @default.
• W2014689871 cites W2059648338 @default.
• W2014689871 cites W2060103844 @default.
• W2014689871 cites W2062258664 @default.
• W2014689871 cites W2068286952 @default.
• W2014689871 cites W2068637796 @default.
• W2014689871 cites W2073050025 @default.
• W2014689871 cites W2095072818 @default.
• W2014689871 cites W2098225784 @default.
• W2014689871 cites W2118262335 @default.
• W2014689871 cites W2122901111 @default.
• W2014689871 cites W2125292377 @default.
• W2014689871 cites W2164317197 @default.
• W2014689871 doi "https://doi.org/10.1046/j.1440-1681.2000.03212.x" @default.
• W2014689871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10696535" @default.
• W2014689871 hasPublicationYear "2000" @default.
• W2014689871 type Work @default.
• W2014689871 sameAs 2014689871 @default.
• W2014689871 citedByCount "22" @default.
• W2014689871 countsByYear W20146898712012 @default.
• W2014689871 countsByYear W20146898712014 @default.
• W2014689871 countsByYear W20146898712015 @default.
• W2014689871 countsByYear W20146898712016 @default.
• W2014689871 countsByYear W20146898712020 @default.
• W2014689871 countsByYear W20146898712023 @default.
• W2014689871 crossrefType "journal-article" @default.
• W2014689871 hasAuthorship W2014689871A5023550849 @default.
• W2014689871 hasAuthorship W2014689871A5032077820 @default.
• W2014689871 hasAuthorship W2014689871A5033822620 @default.
• W2014689871 hasAuthorship W2014689871A5042448049 @default.
• W2014689871 hasAuthorship W2014689871A5048010894 @default.
• W2014689871 hasAuthorship W2014689871A5073458173 @default.
• W2014689871 hasConcept C120770815 @default.
• W2014689871 hasConcept C126322002 @default.
• W2014689871 hasConcept C181199279 @default.
• W2014689871 hasConcept C185592680 @default.
• W2014689871 hasConcept C2775914622 @default.
• W2014689871 hasConcept C2777037550 @default.
• W2014689871 hasConcept C2777622882 @default.
• W2014689871 hasConcept C2778553927 @default.
• W2014689871 hasConcept C2908937200 @default.
• W2014689871 hasConcept C42219234 @default.
• W2014689871 hasConcept C519581460 @default.
• W2014689871 hasConcept C55493867 @default.
• W2014689871 hasConcept C71924100 @default.
• W2014689871 hasConceptScore W2014689871C120770815 @default.
• W2014689871 hasConceptScore W2014689871C126322002 @default.
• W2014689871 hasConceptScore W2014689871C181199279 @default.
• W2014689871 hasConceptScore W2014689871C185592680 @default.
• W2014689871 hasConceptScore W2014689871C2775914622 @default.
• W2014689871 hasConceptScore W2014689871C2777037550 @default.
• W2014689871 hasConceptScore W2014689871C2777622882 @default.
• W2014689871 hasConceptScore W2014689871C2778553927 @default.
• W2014689871 hasConceptScore W2014689871C2908937200 @default.
• W2014689871 hasConceptScore W2014689871C42219234 @default.
• W2014689871 hasConceptScore W2014689871C519581460 @default.
• W2014689871 hasConceptScore W2014689871C55493867 @default.
• W2014689871 hasConceptScore W2014689871C71924100 @default.
• W2014689871 hasIssue "1-2" @default.
• W2014689871 hasLocation W20146898711 @default.
• W2014689871 hasLocation W20146898712 @default.
• W2014689871 hasOpenAccess W2014689871 @default.
• W2014689871 hasPrimaryLocation W20146898711 @default.
• W2014689871 hasRelatedWork W1509822090 @default.
• W2014689871 hasRelatedWork W164278119 @default.
• W2014689871 hasRelatedWork W1969728445 @default.
• W2014689871 hasRelatedWork W1971066171 @default.
• W2014689871 hasRelatedWork W2003803034 @default.
• W2014689871 hasRelatedWork W2010088778 @default.

• next