FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014693614> ?p ?o ?g. }

• W2014693614 endingPage "e71158" @default.
• W2014693614 startingPage "e71158" @default.
• W2014693614 abstract "Background Recent landmark studies have profiled cancer cell lines for molecular features, along with measuring the corresponding growth inhibitory effects for specific drug compounds. These data present a tool for determining which subsets of human cancer might be more responsive to particular drugs. To this end, the NCI-DREAM-sponsored DREAM7: Drug Sensitivity Prediction Challenge (sub-challenge 1) set out to predict the sensitivities of 18 breast cancer cell lines to 31 previously untested compounds, on the basis of molecular profiling data and a training subset of cell lines. Methods and Results With 47 teams submitting blinded predictions, team Creighton scored third in terms of overall accuracy. Team Creighton's method was simple and straightforward, incorporated multiple expression data types (RNA-seq, gene array, RPPA), and incorporated all profiled features (not only the “best” predictive ones). As an extension of the approach, cell line data, from public datasets of expression profiling coupled with drug sensitivities (Barretina, Garnett, Heiser) were used to “predict” the drug sensitivities in human breast tumors (using data from The Cancer Genome Atlas). Drug sensitivity correlations within human breast tumors showed differences by expression-based subtype, with many associations in line with the expected (e.g. Lapatinib sensitivity in HER2-enriched cancers) and others inviting further study (e.g. relative resistance to PI3K inhibitors in basal-like cancers). Conclusions Molecular patterns associated with drug sensitivity are widespread, with potentially hundreds of genes that could be incorporated into making predictions, as well as offering biological clues as to the mechanisms involved. Applying the cell line patterns to human tumor data may help generate hypotheses on what tumor subsets might be more responsive to therapies, where multiple cell line datasets representing various drugs may be used, in order to assess consistency of patterns." @default.
• W2014693614 created "2016-06-24" @default.
• W2014693614 creator A5049425681 @default.
• W2014693614 date "2013-12-27" @default.
• W2014693614 modified "2023-09-27" @default.
• W2014693614 title "Widespread Molecular Patterns Associated with Drug Sensitivity in Breast Cancer Cell Lines, with Implications for Human Tumors" @default.
• W2014693614 cites W2043398720 @default.
• W2014693614 cites W2096283457 @default.
• W2014693614 cites W2105376289 @default.
• W2014693614 cites W2115950635 @default.
• W2014693614 cites W2125789330 @default.
• W2014693614 cites W2128613144 @default.
• W2014693614 cites W2159686118 @default.
• W2014693614 cites W2162946128 @default.
• W2014693614 doi "https://doi.org/10.1371/journal.pone.0071158" @default.
• W2014693614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3873899" @default.
• W2014693614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24386073" @default.
• W2014693614 hasPublicationYear "2013" @default.
• W2014693614 type Work @default.
• W2014693614 sameAs 2014693614 @default.
• W2014693614 citedByCount "6" @default.
• W2014693614 countsByYear W20146936142015 @default.
• W2014693614 countsByYear W20146936142016 @default.
• W2014693614 countsByYear W20146936142017 @default.
• W2014693614 countsByYear W20146936142020 @default.
• W2014693614 countsByYear W20146936142023 @default.
• W2014693614 crossrefType "journal-article" @default.
• W2014693614 hasAuthorship W2014693614A5049425681 @default.
• W2014693614 hasBestOaLocation W20146936141 @default.
• W2014693614 hasConcept C104317684 @default.
• W2014693614 hasConcept C121608353 @default.
• W2014693614 hasConcept C150194340 @default.
• W2014693614 hasConcept C18431079 @default.
• W2014693614 hasConcept C2777329042 @default.
• W2014693614 hasConcept C2779786085 @default.
• W2014693614 hasConcept C2994372470 @default.
• W2014693614 hasConcept C530470458 @default.
• W2014693614 hasConcept C54355233 @default.
• W2014693614 hasConcept C60644358 @default.
• W2014693614 hasConcept C70721500 @default.
• W2014693614 hasConcept C71924100 @default.
• W2014693614 hasConcept C86803240 @default.
• W2014693614 hasConcept C96232424 @default.
• W2014693614 hasConceptScore W2014693614C104317684 @default.
• W2014693614 hasConceptScore W2014693614C121608353 @default.
• W2014693614 hasConceptScore W2014693614C150194340 @default.
• W2014693614 hasConceptScore W2014693614C18431079 @default.
• W2014693614 hasConceptScore W2014693614C2777329042 @default.
• W2014693614 hasConceptScore W2014693614C2779786085 @default.
• W2014693614 hasConceptScore W2014693614C2994372470 @default.
• W2014693614 hasConceptScore W2014693614C530470458 @default.
• W2014693614 hasConceptScore W2014693614C54355233 @default.
• W2014693614 hasConceptScore W2014693614C60644358 @default.
• W2014693614 hasConceptScore W2014693614C70721500 @default.
• W2014693614 hasConceptScore W2014693614C71924100 @default.
• W2014693614 hasConceptScore W2014693614C86803240 @default.
• W2014693614 hasConceptScore W2014693614C96232424 @default.
• W2014693614 hasIssue "12" @default.
• W2014693614 hasLocation W20146936141 @default.
• W2014693614 hasLocation W20146936142 @default.
• W2014693614 hasLocation W20146936143 @default.
• W2014693614 hasLocation W20146936144 @default.
• W2014693614 hasLocation W20146936145 @default.
• W2014693614 hasOpenAccess W2014693614 @default.
• W2014693614 hasPrimaryLocation W20146936141 @default.
• W2014693614 hasRelatedWork W12958539 @default.
• W2014693614 hasRelatedWork W1893617572 @default.
• W2014693614 hasRelatedWork W1989715828 @default.
• W2014693614 hasRelatedWork W2022756254 @default.
• W2014693614 hasRelatedWork W2069630982 @default.
• W2014693614 hasRelatedWork W2093345785 @default.
• W2014693614 hasRelatedWork W2122223946 @default.
• W2014693614 hasRelatedWork W2406633464 @default.
• W2014693614 hasRelatedWork W2599763228 @default.
• W2014693614 hasRelatedWork W3093909612 @default.
• W2014693614 hasVolume "8" @default.
• W2014693614 isParatext "false" @default.
• W2014693614 isRetracted "false" @default.
• W2014693614 magId "2014693614" @default.
• W2014693614 workType "article" @default.