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- W2014696622 abstract "In this week's Lancet, investigators from the Million Women Study (MWS) report important results on the extensively studied but incompletely understood relation between menopausal hormones and risk of endometrial cancer. Most epidemiological studies focus on oestrogens alone, which are used mainly by hysterectomised women. For women with an intact uterus, present formulations involve combined oestrogen-progestagen therapy, on the basis of findings that progestagens counteract the proliferative effects of unopposed oestrogens on endometrial tissue. 1 Ferenczy A Gelfand M The biologic significance of cytologic atypia in progestogen-treated endometrial hyperplasia. Am J Obstet Gynecol. 1989; 160: 126-131 Summary Full Text PDF PubMed Scopus (219) Google Scholar However, there are several unresolved questions, including how progestagens should be prescribed and the effects of extended use. 2 Grady D Ernster VL Hormone replacement therapy and endometrial cancer: are current regimens safe?. J Natl Cancer Inst. 1997; 89: 1088-1089 Crossref PubMed Scopus (43) Google Scholar Endometrial cancer and hormone-replacement therapy in the Million Women StudyOestrogens and tibolone increase the risk of endometrial cancer. Progestagens counteract the adverse effect of oestrogens on the endometrium, the effect being greater the more days every month that they are added to oestrogen and the more obese that women are. However, combined oestrogen-progestagen HRT causes a greater increase in breast cancer than the other therapies do. Thus, when endometrial and breast cancers are added together, there is a greater increase in total cancer incidence with use of combined HRT, both continuous and cyclic, than with use of the other therapies. Full-Text PDF" @default.
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- W2014696622 title "Hormones and endometrial cancer—new data from the Million Women Study" @default.
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- W2014696622 doi "https://doi.org/10.1016/s0140-6736(05)66431-8" @default.
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