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- W2014697720 abstract "Cholinesterase inhibitors (ChEIs), currently the only approved pharmacological agents for the cognitive treatment of Alzheimer's disease and other dementias, are used with the expectation that blocking hydrolysis will benefit memory by elevating brain levels of acetylcholine (ACh). Responsiveness to ChEIs may be dependent on such variables as extent of cholinergic neuron loss, presence of axonal sprouting, subtypes of ChEs, or developmental factors regulating ChE expression in aging. Other non-neuronal targets of increased ACh may influence immune function and cerebral blood flow. In addition to blocking the hydrolytic effects of acetylcholinesterase (AChE), ChEIs may also inhibit some novel, nonhydrolytic actions of ChEs, including glial and neuronal differentiation. ChEs are homologous to cell adhesion molecules, and can increase the survival and the outgrowth of neurites and stimulate synaptogenesis in dopaminergic substantia nigra neurons in culture, while a variety of ChEIs induce defasciculation of neurite bundles and block cell-cell or cell-substrate adhesion. In addition, AChE promotes the assembly of amyloid peptide into stable, neurotoxic complexes, which may contribute to the selective neuronal loss and production of plaques and tangles in AD, suggesting a novel beneficial role of ChEIs. P77" @default.
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- W2014697720 date "1999-09-01" @default.
- W2014697720 modified "2023-09-27" @default.
- W2014697720 title "EXPANDING THE BOUNDARIES: A CONCEPTUAL OVERVIEW OF NOVEL MECHANISMS OF CHOLINESTERASE INHIBITORS IN THE TREATMENT OF DEMENTIA" @default.
- W2014697720 doi "https://doi.org/10.1097/00019442-199911001-00140" @default.
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