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- W2014697941 endingPage "284" @default.
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- W2014697941 abstract "Reactive oxygen intermediates (ROI) and other pro-oxidant agents are known to elicit, in vivo and in vitro, oxidative decomposition of omega-3 and omega-6 polyunsaturated fatty acids of membrane phospholipids (i.e, lipid peroxidation). This leads to the formation of a complex mixture of aldehydic end-products, including malonyldialdehyde (MDA), 4-hydroxy-2,3-nonenal (HNE), and other 4-hydroxy-2,3-alkenals (HAKs) of different chain length. These aldehydic molecules have been considered originally as ultimate mediators of toxic effects elicited by oxidative stress occurring in biological material. Experimental and clinical evidence coming from different laboratories now suggests that HNE and HAKs can also act as bioactive molecules in either physiological and pathological conditions. These aldehydic compounds can affect and modulate, at very low and nontoxic concentrations, several cell functions, including signal transduction, gene expression, cell proliferation, and, more generally, the response of the target cell(s). In this review article, we would like to offer an up-to-date review on this particular aspect of oxidative stress--dependent modulation of cellular functions-as well as to offer comments on the related pathophysiological implications, with special reference to human conditions of disease." @default.
- W2014697941 created "2016-06-24" @default.
- W2014697941 creator A5031576111 @default.
- W2014697941 creator A5032704680 @default.
- W2014697941 creator A5045019834 @default.
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- W2014697941 creator A5074623692 @default.
- W2014697941 date "1999-09-01" @default.
- W2014697941 modified "2023-10-15" @default.
- W2014697941 title "4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications" @default.
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