FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014698810> ?p ?o ?g. }

• W2014698810 endingPage "56" @default.
• W2014698810 startingPage "47" @default.
• W2014698810 abstract "Despite improvements in emergency treatment, myocardial infarction is often the beginning of a downward spiral leading to congestive heart failure. Other than heart transplantation, current therapeutic means aim at enabling the organism to survive with a heart that is working at a fraction of its original capacity. It is therefore no surprise that cardiac stem cell therapy has raised many hopes. However, neither the ideal source and type of stem cell nor the critical cell number and mode of application have been defined so far. Early reports on myocardial repair by adult bone marrow stem cells from rodent models promoted an unparalleled boost of clinical and experimental cell therapy studies. The phenomenon of stem/progenitor cell-induced angiogenesis in ischemic myocardium has ever since been reproduced by numerous groups in a variety of small and large animal models. Myogenesis, however, is an altogether different matter. Many of the initial clinical studies were fueled by the suggestion that early hematopoietic stem cells have a plasticity high enough to enable cross-lineage differentiation into cells of cardiomyocyte phenotype, but the initial enthusiasm has largely faded. The myogenic potential of stroma cell-derived mesenchymal stem cells is much better documented in animal models, but transfer to the clinical setting faces a variety of obstacles. In clinical pilot trials, we and others have demonstrated the feasibility and safety of administering progenitor cells derived from autologous bone marrow to the myocardium of patients with ischemic heart disease. Clinical efficacy data are still rare, but the few controlled trials that have been completed uniformly show a tendency towards better heart function in cell-treated patients. This review is an attempt to describe the scientific basis for cardiac cell therapy from the point of view of the clinician, focusing on problems that arise with beginning translation into the clinical setting." @default.
• W2014698810 created "2016-06-24" @default.
• W2014698810 creator A5015144738 @default.
• W2014698810 creator A5046215274 @default.
• W2014698810 creator A5055249856 @default.
• W2014698810 creator A5072408501 @default.
• W2014698810 date "2006-01-01" @default.
• W2014698810 modified "2023-09-23" @default.
• W2014698810 title "Stem Cell Therapy for Ischemic Heart Disease: Beginning or End of the Road?" @default.
• W2014698810 cites W1502896205 @default.
• W2014698810 cites W1569560733 @default.
• W2014698810 cites W1631250427 @default.
• W2014698810 cites W1964058577 @default.
• W2014698810 cites W1970590929 @default.
• W2014698810 cites W1977437881 @default.
• W2014698810 cites W1979103623 @default.
• W2014698810 cites W1981648879 @default.
• W2014698810 cites W1985395658 @default.
• W2014698810 cites W1991409486 @default.
• W2014698810 cites W2009378279 @default.
• W2014698810 cites W2028036560 @default.
• W2014698810 cites W2028519194 @default.
• W2014698810 cites W2035582618 @default.
• W2014698810 cites W2036525653 @default.
• W2014698810 cites W2049466721 @default.
• W2014698810 cites W2053704719 @default.
• W2014698810 cites W2056511195 @default.
• W2014698810 cites W2064788345 @default.
• W2014698810 cites W2068380542 @default.
• W2014698810 cites W2072386632 @default.
• W2014698810 cites W2075009901 @default.
• W2014698810 cites W2075344844 @default.
• W2014698810 cites W2075895818 @default.
• W2014698810 cites W2087604634 @default.
• W2014698810 cites W2090041902 @default.
• W2014698810 cites W2091395040 @default.
• W2014698810 cites W2096650620 @default.
• W2014698810 cites W2098743872 @default.
• W2014698810 cites W2098892229 @default.
• W2014698810 cites W2103054294 @default.
• W2014698810 cites W2108017566 @default.
• W2014698810 cites W2108771801 @default.
• W2014698810 cites W2109680555 @default.
• W2014698810 cites W2112267683 @default.
• W2014698810 cites W2113551024 @default.
• W2014698810 cites W2116836369 @default.
• W2014698810 cites W2119546710 @default.
• W2014698810 cites W2125155374 @default.
• W2014698810 cites W2125417661 @default.
• W2014698810 cites W2125931106 @default.
• W2014698810 cites W2127872440 @default.
• W2014698810 cites W2131388270 @default.
• W2014698810 cites W2134704099 @default.
• W2014698810 cites W2136120513 @default.
• W2014698810 cites W2139379741 @default.
• W2014698810 cites W2142207476 @default.
• W2014698810 cites W2143677869 @default.
• W2014698810 cites W2147164277 @default.
• W2014698810 cites W2151420887 @default.
• W2014698810 cites W2151722542 @default.
• W2014698810 cites W2154502936 @default.
• W2014698810 cites W2156965571 @default.
• W2014698810 cites W2157289201 @default.
• W2014698810 cites W2158610924 @default.
• W2014698810 cites W2159999899 @default.
• W2014698810 cites W2160648938 @default.
• W2014698810 cites W2164506013 @default.
• W2014698810 cites W2317288391 @default.
• W2014698810 cites W25713228 @default.
• W2014698810 cites W4240228014 @default.
• W2014698810 cites W4243820570 @default.
• W2014698810 doi "https://doi.org/10.3727/000000006783982313" @default.
• W2014698810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16826795" @default.
• W2014698810 hasPublicationYear "2006" @default.
• W2014698810 type Work @default.
• W2014698810 sameAs 2014698810 @default.
• W2014698810 citedByCount "47" @default.
• W2014698810 countsByYear W20146988102012 @default.
• W2014698810 countsByYear W20146988102013 @default.
• W2014698810 countsByYear W20146988102016 @default.
• W2014698810 countsByYear W20146988102021 @default.
• W2014698810 crossrefType "journal-article" @default.
• W2014698810 hasAuthorship W2014698810A5015144738 @default.
• W2014698810 hasAuthorship W2014698810A5046215274 @default.
• W2014698810 hasAuthorship W2014698810A5055249856 @default.
• W2014698810 hasAuthorship W2014698810A5072408501 @default.
• W2014698810 hasBestOaLocation W20146988101 @default.
• W2014698810 hasConcept C10882517 @default.
• W2014698810 hasConcept C126322002 @default.
• W2014698810 hasConcept C142724271 @default.
• W2014698810 hasConcept C198826908 @default.
• W2014698810 hasConcept C201750760 @default.
• W2014698810 hasConcept C2778198053 @default.
• W2014698810 hasConcept C2779389132 @default.
• W2014698810 hasConcept C2780007613 @default.
• W2014698810 hasConcept C28328180 @default.
• W2014698810 hasConcept C71924100 @default.
• W2014698810 hasConcept C86803240 @default.

• next