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- W2014702017 abstract "A simple, efficient, and flexible procedure for the synthesis of chiral, amphiphilic, and water-soluble macrocycles is reported. Acylation of p-xylylenediamine with N-Fmoc-protected glycine, -aspartic acid, -glutamic acid, and -arginine, followed by removal of Fmoc-groups, gave amino acid:p-xylylene conjugate diamines, which were converted to ten macrocycles via stepwise urea formation using p-nitrophenyl chloroformate. -Aspartic acid-containing macrocyles proved to be soluble in aqueous buffers and a macrocycle containing four aspartate residues was found to recognize arginine and arginine esters with moderate affinity." @default.
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- W2014702017 date "2003-09-01" @default.
- W2014702017 modified "2023-09-26" @default.
- W2014702017 title "Synthesis of chiral, amphiphilic, and water-soluble macrocycles via urea formation" @default.
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- W2014702017 doi "https://doi.org/10.1016/j.tet.2003.08.019" @default.
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