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• W2014704844 abstract "No AccessJournal of UrologyAdult Urology: Sexual Function/Infertility1 Jun 2005VARDENAFIL IMPROVED PATIENT SATISFACTION WITH ERECTILE HARDNESS, ORGASMIC FUNCTION AND SEXUAL EXPERIENCE IN MEN WITH ERECTILE DYSFUNCTION FOLLOWING NERVE SPARING RADICAL PROSTATECTOMY AJAY NEHRA, JOHN GRANTMYRE, ANDREA NADEL, MARC THIBONNIER, and GERALD BROCK AJAY NEHRAAJAY NEHRA More articles by this author , JOHN GRANTMYREJOHN GRANTMYRE Financial interest and/or other relationship with Bayer Pharmaceuticals. More articles by this author , ANDREA NADELANDREA NADEL Financial interest and/or other relationship with Bayer Pharmaceuticals. More articles by this author , MARC THIBONNIERMARC THIBONNIER Financial interest and/or other relationship with Bayer Pharmaceuticals. More articles by this author , and GERALD BROCKGERALD BROCK Financial interest and/or other relationship with Bayer/GlaxoSmithKline, Lilly-ICOS and Pfizer. More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000158456.41788.93AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Nerve sparing radical retropubic prostatectomy (NS-RRP) results in erectile dysfunction in a significant number of patients. Vardenafil, a potent and selective phosphodiesterase type 5 inhibitor, is generally safe. It improves International Index of Erectile Function erectile function domain scores, and penetration and erection maintenance success rates in patients who have undergone NS-RRP. We report additional parameters important to patient perceptions regarding erection quality and satisfaction with sexual experience following NS-RRP. Materials and Methods: A total of 440 men at 58 centers throughout the United States and Canada participated in this randomized, placebo controlled, double-blind trial with 3 phases, namely baseline (4-week untreated period), treatment (12 weeks) and followup (7 days). Participants received placebo (145), 10 mg vardenafil (146) or 20 mg vardenafil (149) at home on demand but no more than once per calendar day. Efficacy and satisfaction with erection quality and sexual experience were determined during the trial. Results: The 10 and 20 mg vardenafil doses were significantly superior to placebo for the International Index of Erectile Function domains for intercourse satisfaction, orgasmic function and overall satisfaction with sexual experience (vs placebo p <0.0009). Significant improvement in the satisfaction rate with erection hardness were demonstrated for each vardenafil dose compared with placebo (p <0.0001). Vardenafil was generally well tolerated. Common adverse events were headache, vasodilatation and rhinitis. Conclusions: In this difficult to treat population of men with erectile dysfunction subsequent to NS-RRP on demand treatment with vardenafil during a 3-month period significantly improved key aspects of the sexual experience important to patient quality of life. References 1 : Cancer statistics, 2002. CA Cancer J Clin2002; 52: 23. Google Scholar 2 : Erectile function after radical prostatectomy: a review. Eur Urol2003; 43: 95. Google Scholar 3 : Erectile function after radical prostatectomy. Semin Urol, Oncol2000; 18: 71. Google Scholar 4 : Sex or survival: trade-offs between quality and quantity of life. J Clin Oncol1991; 9: 328. Google Scholar 5 : Patient attitudes regarding treatment-related erectile dysfunction at time of early detection of prostate cancer. Urology1997; 50: 704. Google Scholar 6 : Factors predicting recovery of erections after radical prostatectomy. J Urol2000; 164: 1929. Link, Google Scholar 7 : Sexual function and bother after radical prostatectomy or radiation for prostate cancer: multivariate quality-of-life analysis from CaPSURE. Cancer of the Prostate Strategic Urologic Research Endeavor. Urology1999; 54: 503. Google Scholar 8 : Quality of life and sexuality following radical prostatectomy in patients with prostate cancer who use or do not use erectile aids. Urology1997; 50: 740. Google Scholar 9 : Management of erectile dysfunction following radical prostatectomy. Curr Urol Rep2001; 2: 495. Google Scholar 10 : Treatment of erectile dysfunction after radical prostatectomy with sildenafil citrate (Viagra). Urology1998; 52: 963. Google Scholar 11 : Role of Viagra after radical prostatectomy. Urology2000; 55: 241. Google Scholar 12 : Efficacy of sildenafil in erectile dysfunction after radical prostatectomy. Int J Impot Res2000; 12: 165. Google Scholar 13 : Effect of sildenafil citrate on post-radical prostatectomy erectile dysfunction. J Urol2000; 164: 1935. Link, Google Scholar 14 : Sildenafil citrate after radical retropubic prostatectomy. J Urol1999; 162: 1614. Link, Google Scholar 15 : Sustained efficacy and tolerability of vardenafil, a highly potent selective phosphodiesterase type 5 inhibitor, in men with erectile dysfunction: results of a randomized, double-blind, 26-week placebo-controlled pivotal trial. Urology2003; 61: 8. Google Scholar 16 : Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial. J Androl2002; 23: 763. Google Scholar 17 : Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy. J Urol2003; 170: 1278. Link, Google Scholar 18 : On life satisfaction in male erectile dysfunction. Int J Impot Res1997; 9: 141. Google Scholar 19 : The effect of erectile dysfunction on the quality of life of men after radical prostatectomy. BJU Int2003; 92: 929. Google Scholar Department of Urology, Mayo Clinic (AN), Rochester, Minnesota, Dalhousie University (JG), Halifax, Nova Scotia, and Lawson Research Institute, St. Joseph’s Health Centre, University of Western Ontario (GB), London, Ontario, Canada, and Bayer Pharmaceuticals Corp. (AN, MT), West Haven, Connecticut© 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByDu K, Zhang C, Presson A, Tward J, Brant W and Dechet C (2018) Orgasmic Function after Radical ProstatectomyJournal of Urology, VOL. 198, NO. 2, (407-413), Online publication date: 1-Aug-2017. Volume 173Issue 6June 2005Page: 2067-2071 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Keywordsprostatectomyphosphodiesterase inhibitorsimpotencepenisMetricsAuthor Information AJAY NEHRA More articles by this author JOHN GRANTMYRE Financial interest and/or other relationship with Bayer Pharmaceuticals. More articles by this author ANDREA NADEL Financial interest and/or other relationship with Bayer Pharmaceuticals. More articles by this author MARC THIBONNIER Financial interest and/or other relationship with Bayer Pharmaceuticals. More articles by this author GERALD BROCK Financial interest and/or other relationship with Bayer/GlaxoSmithKline, Lilly-ICOS and Pfizer. More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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