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• W2014705874 abstract "Cochlear stria vascularis contains melanin-producing intermediate cells that play a critical role in the production of the endocochlear potential (EP) and in maintaining the high levels of K+ that normally exist in scala media. The melanin produced by intermediate cells can be exported to the intrastrial space, where it may be taken up by strial marginal cells and basal cells. Because melanin can act as an antioxidant and metal chelator, evidence for its role in protecting the stria and organ of Corti against noise, ototoxins, and aging has long been sought. While some evidence supports a protective role of melanin against noise and ototoxins, no evidence yet presented has demonstrated a clear role for melanin in maintaining the EP during aging. We tested this by comparing basal turn EPs and a host of cochlear cellular metrics in aging C57BL/6 (B6) mice and C57BL/6-Tyrc-2J mice. The latter mice carry a naturally occurring inactivating mutation of the tyrosinase locus, and produce no strial melanin. Because these two strains are coisogenic, and because pigmented B6 mice show essentially no age-related EP decline, they provide an ideal test of importance of melanin in the aging stria. Pigmented and albino B6 mice showed identical rates of hearing loss and sensory cell loss. However, after two years of age, basal turn EPs significantly diverged, with 42% of albinos showing EPs below 100 mV versus only 18% of pigmented mice. The clearest anatomical correlate of this EP difference was significantly reduced strial thickness in the albinos that was highly correlated with loss of marginal cells. Combined with findings in human temporal bones, plus recent work in BALB/c mice and gerbils, the present findings point to a common etiology in strial presbycusis whereby EP reduction is principally linked to marginal cell loss or dysfunction. For any individual, genetic background, environmental influences, and stochastic events may work together to determine whether marginal cell density or function falls below some critical level, and thus whether EP decline occurs." @default.
• W2014705874 created "2016-06-24" @default.
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• W2014705874 creator A5037849815 @default.
• W2014705874 creator A5070897634 @default.
• W2014705874 creator A5080394338 @default.
• W2014705874 date "2009-03-01" @default.
• W2014705874 modified "2023-10-07" @default.
• W2014705874 title "Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline" @default.
• W2014705874 cites W1916040231 @default.
• W2014705874 cites W1969826686 @default.
• W2014705874 cites W1971812638 @default.
• W2014705874 cites W1976723773 @default.
• W2014705874 cites W1978119285 @default.
• W2014705874 cites W1978210459 @default.
• W2014705874 cites W1985782120 @default.
• W2014705874 cites W1987283028 @default.
• W2014705874 cites W1987507254 @default.
• W2014705874 cites W1987722930 @default.
• W2014705874 cites W1990254682 @default.
• W2014705874 cites W1990342083 @default.
• W2014705874 cites W1990549525 @default.
• W2014705874 cites W1992171268 @default.
• W2014705874 cites W1994924588 @default.
• W2014705874 cites W1997078287 @default.
• W2014705874 cites W1999430689 @default.
• W2014705874 cites W1999893307 @default.
• W2014705874 cites W2000104291 @default.
• W2014705874 cites W2000554665 @default.
• W2014705874 cites W2001215207 @default.
• W2014705874 cites W2001835309 @default.
• W2014705874 cites W2003287089 @default.
• W2014705874 cites W2006086425 @default.
• W2014705874 cites W2007348919 @default.
• W2014705874 cites W2009221707 @default.
• W2014705874 cites W2011306112 @default.
• W2014705874 cites W2011847603 @default.
• W2014705874 cites W2012095162 @default.
• W2014705874 cites W2016043320 @default.
• W2014705874 cites W2017994420 @default.
• W2014705874 cites W2019359136 @default.
• W2014705874 cites W2020298725 @default.
• W2014705874 cites W2021060205 @default.
• W2014705874 cites W2021465286 @default.
• W2014705874 cites W2023194082 @default.
• W2014705874 cites W2026627305 @default.
• W2014705874 cites W2028660773 @default.
• W2014705874 cites W2031198782 @default.
• W2014705874 cites W2031375292 @default.
• W2014705874 cites W2042412262 @default.
• W2014705874 cites W2043297221 @default.
• W2014705874 cites W2044804260 @default.
• W2014705874 cites W2045989843 @default.
• W2014705874 cites W2048579894 @default.
• W2014705874 cites W2052848847 @default.
• W2014705874 cites W2057723728 @default.
• W2014705874 cites W2062910183 @default.
• W2014705874 cites W2065620411 @default.
• W2014705874 cites W2066709167 @default.
• W2014705874 cites W2073748140 @default.
• W2014705874 cites W2074233512 @default.
• W2014705874 cites W2074254430 @default.
• W2014705874 cites W2076350323 @default.
• W2014705874 cites W2076996200 @default.
• W2014705874 cites W2078045632 @default.
• W2014705874 cites W2085793489 @default.
• W2014705874 cites W2088841836 @default.
• W2014705874 cites W2098018151 @default.
• W2014705874 cites W2098959714 @default.
• W2014705874 cites W2099243834 @default.
• W2014705874 cites W2103647977 @default.
• W2014705874 cites W2106101149 @default.
• W2014705874 cites W2124658900 @default.
• W2014705874 cites W2137220151 @default.
• W2014705874 cites W2137358269 @default.
• W2014705874 cites W2142092370 @default.
• W2014705874 cites W2145490605 @default.
• W2014705874 cites W2158244678 @default.
• W2014705874 cites W2159130722 @default.
• W2014705874 cites W2160378963 @default.
• W2014705874 cites W2160697076 @default.
• W2014705874 cites W2165400940 @default.
• W2014705874 cites W2207862634 @default.
• W2014705874 cites W2212098768 @default.
• W2014705874 cites W2268695670 @default.
• W2014705874 cites W2324871389 @default.
• W2014705874 cites W2912179861 @default.
• W2014705874 doi "https://doi.org/10.1016/j.heares.2008.12.005" @default.
• W2014705874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19141317" @default.
• W2014705874 hasPublicationYear "2009" @default.
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