Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014710826> ?p ?o ?g. }
- W2014710826 endingPage "6185" @default.
- W2014710826 startingPage "6181" @default.
- W2014710826 abstract "Escherichia coli responds to superoxide-generating agents by inducing approximately 40 proteins. We have identified a genetic locus, soxR (superoxide response), that positively regulates 9 of these proteins during superoxide stress. Induction under soxR control is at the transcriptional level, as shown with lac fusions to five paraquat-inducible promoters. Members of the soxR regulon include at least three proteins with demonstrable antioxidant roles: Mn-containing superoxide dismutase (which destroys superoxide radicals), endonuclease IV (which repairs radical-induced damages in DNA), and glucose-6-phosphate dehydrogenase (which produces NADPH). Induction of the soxR regulon also leads to diminished levels of the major outer membrane protein OmpF and alteration of the small-subunit ribosomal protein S6. These latter changes confer resistance to a variety of antibiotics. The soxR regulon may thus operate as an inducible defense against xenobiotics in general." @default.
- W2014710826 created "2016-06-24" @default.
- W2014710826 creator A5002689529 @default.
- W2014710826 creator A5023057218 @default.
- W2014710826 creator A5026129168 @default.
- W2014710826 creator A5032046529 @default.
- W2014710826 creator A5082909035 @default.
- W2014710826 date "1990-08-01" @default.
- W2014710826 modified "2023-10-18" @default.
- W2014710826 title "Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli." @default.
- W2014710826 cites W1503950878 @default.
- W2014710826 cites W1509038183 @default.
- W2014710826 cites W1509993364 @default.
- W2014710826 cites W1540626794 @default.
- W2014710826 cites W1560746966 @default.
- W2014710826 cites W1566235420 @default.
- W2014710826 cites W1572693909 @default.
- W2014710826 cites W1583063946 @default.
- W2014710826 cites W1584772112 @default.
- W2014710826 cites W1690379440 @default.
- W2014710826 cites W1894520368 @default.
- W2014710826 cites W1906144591 @default.
- W2014710826 cites W1917998177 @default.
- W2014710826 cites W1939685797 @default.
- W2014710826 cites W1958517645 @default.
- W2014710826 cites W1972168834 @default.
- W2014710826 cites W1995568065 @default.
- W2014710826 cites W1999200892 @default.
- W2014710826 cites W2017492242 @default.
- W2014710826 cites W2024122764 @default.
- W2014710826 cites W2027891270 @default.
- W2014710826 cites W2046193921 @default.
- W2014710826 cites W2047560791 @default.
- W2014710826 cites W2053435759 @default.
- W2014710826 cites W2053846450 @default.
- W2014710826 cites W2072298605 @default.
- W2014710826 cites W2073058011 @default.
- W2014710826 cites W2091569327 @default.
- W2014710826 cites W2095088178 @default.
- W2014710826 cites W2101422765 @default.
- W2014710826 cites W2146802614 @default.
- W2014710826 cites W2165142006 @default.
- W2014710826 cites W2172209113 @default.
- W2014710826 cites W2176312424 @default.
- W2014710826 cites W2916217134 @default.
- W2014710826 doi "https://doi.org/10.1073/pnas.87.16.6181" @default.
- W2014710826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/54496" @default.
- W2014710826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1696718" @default.
- W2014710826 hasPublicationYear "1990" @default.
- W2014710826 type Work @default.
- W2014710826 sameAs 2014710826 @default.
- W2014710826 citedByCount "513" @default.
- W2014710826 countsByYear W20147108262012 @default.
- W2014710826 countsByYear W20147108262013 @default.
- W2014710826 countsByYear W20147108262014 @default.
- W2014710826 countsByYear W20147108262015 @default.
- W2014710826 countsByYear W20147108262016 @default.
- W2014710826 countsByYear W20147108262017 @default.
- W2014710826 countsByYear W20147108262018 @default.
- W2014710826 countsByYear W20147108262019 @default.
- W2014710826 countsByYear W20147108262020 @default.
- W2014710826 countsByYear W20147108262021 @default.
- W2014710826 countsByYear W20147108262022 @default.
- W2014710826 countsByYear W20147108262023 @default.
- W2014710826 crossrefType "journal-article" @default.
- W2014710826 hasAuthorship W2014710826A5002689529 @default.
- W2014710826 hasAuthorship W2014710826A5023057218 @default.
- W2014710826 hasAuthorship W2014710826A5026129168 @default.
- W2014710826 hasAuthorship W2014710826A5032046529 @default.
- W2014710826 hasAuthorship W2014710826A5082909035 @default.
- W2014710826 hasBestOaLocation W20147108261 @default.
- W2014710826 hasConcept C104317684 @default.
- W2014710826 hasConcept C143425029 @default.
- W2014710826 hasConcept C181199279 @default.
- W2014710826 hasConcept C192396546 @default.
- W2014710826 hasConcept C2775838275 @default.
- W2014710826 hasConcept C2776435897 @default.
- W2014710826 hasConcept C2776527163 @default.
- W2014710826 hasConcept C2778004101 @default.
- W2014710826 hasConcept C2780795997 @default.
- W2014710826 hasConcept C38062823 @default.
- W2014710826 hasConcept C547475151 @default.
- W2014710826 hasConcept C552990157 @default.
- W2014710826 hasConcept C55493867 @default.
- W2014710826 hasConcept C62361671 @default.
- W2014710826 hasConcept C67705224 @default.
- W2014710826 hasConcept C86803240 @default.
- W2014710826 hasConcept C88478588 @default.
- W2014710826 hasConceptScore W2014710826C104317684 @default.
- W2014710826 hasConceptScore W2014710826C143425029 @default.
- W2014710826 hasConceptScore W2014710826C181199279 @default.
- W2014710826 hasConceptScore W2014710826C192396546 @default.
- W2014710826 hasConceptScore W2014710826C2775838275 @default.
- W2014710826 hasConceptScore W2014710826C2776435897 @default.
- W2014710826 hasConceptScore W2014710826C2776527163 @default.
- W2014710826 hasConceptScore W2014710826C2778004101 @default.
- W2014710826 hasConceptScore W2014710826C2780795997 @default.
- W2014710826 hasConceptScore W2014710826C38062823 @default.