Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014714297> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2014714297 endingPage "9747" @default.
- W2014714297 startingPage "9735" @default.
- W2014714297 abstract "A general method has been developed for the expedient solid-phase synthesis of aspartyl protease inhibitors that do not incorporate any amino acids. The synthesis approach was designed to allow the introduction of diverse functionality at all four variable sites in inhibitors 1a,b using readily available precursors. Representative, analytically pure inhibitors were obtained in 45−64% overall yields for the 12-step solid-phase synthesis sequence that includes both stereoselective reduction and carbon−carbon bond forming steps. A library of 204 spatially separate compounds was also prepared and screened against cathepsin D and resulted in the identification of a number of potent small molecule inhibitors (Ki = 0.7−3 nM). The described synthesis approach enables the rapid identification of small molecule inhibitors to diverse aspartyl protease targets. The general design principles are also applicable to other enzyme classes." @default.
- W2014714297 created "2016-06-24" @default.
- W2014714297 creator A5012406363 @default.
- W2014714297 creator A5037547547 @default.
- W2014714297 creator A5077206537 @default.
- W2014714297 date "1998-09-01" @default.
- W2014714297 modified "2023-10-11" @default.
- W2014714297 title "General Solid-Phase Synthesis Approach To Prepare Mechanism-Based Aspartyl Protease Inhibitor Libraries. Identification of Potent Cathepsin D Inhibitors" @default.
- W2014714297 cites W112454059 @default.
- W2014714297 cites W1522940126 @default.
- W2014714297 cites W1971708545 @default.
- W2014714297 cites W2000960726 @default.
- W2014714297 cites W2027095884 @default.
- W2014714297 cites W2028593124 @default.
- W2014714297 cites W2036633666 @default.
- W2014714297 cites W2038268743 @default.
- W2014714297 cites W2060383167 @default.
- W2014714297 cites W2069607377 @default.
- W2014714297 cites W2070295663 @default.
- W2014714297 cites W2071582487 @default.
- W2014714297 cites W2082491230 @default.
- W2014714297 cites W2091379422 @default.
- W2014714297 cites W2123011093 @default.
- W2014714297 cites W2131344835 @default.
- W2014714297 cites W2162303607 @default.
- W2014714297 cites W2164231548 @default.
- W2014714297 cites W2196692354 @default.
- W2014714297 cites W2318289184 @default.
- W2014714297 cites W2427669728 @default.
- W2014714297 cites W2493316313 @default.
- W2014714297 cites W2952645881 @default.
- W2014714297 cites W4247803785 @default.
- W2014714297 doi "https://doi.org/10.1021/ja981812m" @default.
- W2014714297 hasPublicationYear "1998" @default.
- W2014714297 type Work @default.
- W2014714297 sameAs 2014714297 @default.
- W2014714297 citedByCount "51" @default.
- W2014714297 countsByYear W20147142972012 @default.
- W2014714297 countsByYear W20147142972013 @default.
- W2014714297 countsByYear W20147142972014 @default.
- W2014714297 countsByYear W20147142972016 @default.
- W2014714297 countsByYear W20147142972017 @default.
- W2014714297 countsByYear W20147142972019 @default.
- W2014714297 countsByYear W20147142972020 @default.
- W2014714297 countsByYear W20147142972021 @default.
- W2014714297 countsByYear W20147142972022 @default.
- W2014714297 crossrefType "journal-article" @default.
- W2014714297 hasAuthorship W2014714297A5012406363 @default.
- W2014714297 hasAuthorship W2014714297A5037547547 @default.
- W2014714297 hasAuthorship W2014714297A5077206537 @default.
- W2014714297 hasConcept C114373084 @default.
- W2014714297 hasConcept C124790011 @default.
- W2014714297 hasConcept C161624437 @default.
- W2014714297 hasConcept C181199279 @default.
- W2014714297 hasConcept C185592680 @default.
- W2014714297 hasConcept C202751555 @default.
- W2014714297 hasConcept C21951064 @default.
- W2014714297 hasConcept C2776469878 @default.
- W2014714297 hasConcept C2776714187 @default.
- W2014714297 hasConcept C2776980637 @default.
- W2014714297 hasConcept C2779281246 @default.
- W2014714297 hasConcept C55493867 @default.
- W2014714297 hasConcept C71240020 @default.
- W2014714297 hasConceptScore W2014714297C114373084 @default.
- W2014714297 hasConceptScore W2014714297C124790011 @default.
- W2014714297 hasConceptScore W2014714297C161624437 @default.
- W2014714297 hasConceptScore W2014714297C181199279 @default.
- W2014714297 hasConceptScore W2014714297C185592680 @default.
- W2014714297 hasConceptScore W2014714297C202751555 @default.
- W2014714297 hasConceptScore W2014714297C21951064 @default.
- W2014714297 hasConceptScore W2014714297C2776469878 @default.
- W2014714297 hasConceptScore W2014714297C2776714187 @default.
- W2014714297 hasConceptScore W2014714297C2776980637 @default.
- W2014714297 hasConceptScore W2014714297C2779281246 @default.
- W2014714297 hasConceptScore W2014714297C55493867 @default.
- W2014714297 hasConceptScore W2014714297C71240020 @default.
- W2014714297 hasIssue "38" @default.
- W2014714297 hasLocation W20147142971 @default.
- W2014714297 hasOpenAccess W2014714297 @default.
- W2014714297 hasPrimaryLocation W20147142971 @default.
- W2014714297 hasRelatedWork W2001720074 @default.
- W2014714297 hasRelatedWork W2047384542 @default.
- W2014714297 hasRelatedWork W2066549705 @default.
- W2014714297 hasRelatedWork W2134656633 @default.
- W2014714297 hasRelatedWork W2163663571 @default.
- W2014714297 hasRelatedWork W2949560382 @default.
- W2014714297 hasRelatedWork W2951741970 @default.
- W2014714297 hasRelatedWork W3160927361 @default.
- W2014714297 hasRelatedWork W3185899234 @default.
- W2014714297 hasRelatedWork W4255780768 @default.
- W2014714297 hasVolume "120" @default.
- W2014714297 isParatext "false" @default.
- W2014714297 isRetracted "false" @default.
- W2014714297 magId "2014714297" @default.
- W2014714297 workType "article" @default.