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- W2014716069 abstract "Although there is a substantial literature that mitochondria have a crucial role in the aging process, the mechanism has remained elusive. The role of reactive oxygen species, mitochondrial DNA injuries, and a decline in mitochondrial quality control has been proposed. Emerging studies have demonstrated that Krebs cycle intermediates, 2-oxoglutarate (also known as α-ketoglutarate), succinate and fumarate, can regulate the level of DNA and histone methylation. Moreover, citrate, also a Krebs cycle metabolite, can enhance histone acetylation. Genome-wide screening studies have revealed that the aging process is linked to significant epigenetic changes in the chromatin landscape, e.g. global demethylation of DNA and histones and increase in histone acetylation. Interestingly, recent studies have revealed that the demethylases of DNA (TET1-3) and histone lysines (KDM2-7) are members of 2-oxoglutarate-dependent dioxygenases (2-OGDO). The 2-OGDO enzymes are activated by oxygen, iron and the major Krebs cycle intermediate, 2-oxoglutarate, whereas they are inhibited by succinate and fumarate. Considering the endosymbiont origin of mitochondria, it is not surprising that Krebs cycle metabolites can control the gene expression of host cell by modifying the epigenetic landscape of chromatin. It seems that age-related disturbances in mitochondrial metabolism can induce epigenetic reprogramming, which promotes the appearance of senescent phenotype and degenerative diseases." @default.
- W2014716069 created "2016-06-24" @default.
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- W2014716069 date "2014-07-01" @default.
- W2014716069 modified "2023-10-12" @default.
- W2014716069 title "Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process" @default.
- W2014716069 cites W1536059425 @default.
- W2014716069 cites W1965707131 @default.
- W2014716069 cites W1968018974 @default.
- W2014716069 cites W1969204301 @default.
- W2014716069 cites W1969585647 @default.
- W2014716069 cites W1970592702 @default.
- W2014716069 cites W1975472671 @default.
- W2014716069 cites W1976626368 @default.
- W2014716069 cites W1981748085 @default.
- W2014716069 cites W1982409009 @default.
- W2014716069 cites W1997773274 @default.
- W2014716069 cites W1998852095 @default.
- W2014716069 cites W1999886232 @default.
- W2014716069 cites W1999940145 @default.
- W2014716069 cites W2004608668 @default.
- W2014716069 cites W2012848479 @default.
- W2014716069 cites W2016217879 @default.
- W2014716069 cites W2017199534 @default.
- W2014716069 cites W2023155523 @default.
- W2014716069 cites W2023881529 @default.
- W2014716069 cites W2024988671 @default.
- W2014716069 cites W2030548279 @default.
- W2014716069 cites W2031900290 @default.
- W2014716069 cites W2035010201 @default.
- W2014716069 cites W2036229829 @default.
- W2014716069 cites W2036551825 @default.
- W2014716069 cites W2036810172 @default.
- W2014716069 cites W2037899131 @default.
- W2014716069 cites W20418751 @default.
- W2014716069 cites W2054036156 @default.
- W2014716069 cites W2057495460 @default.
- W2014716069 cites W2061106796 @default.
- W2014716069 cites W2061662711 @default.
- W2014716069 cites W2065437731 @default.
- W2014716069 cites W2066186764 @default.
- W2014716069 cites W2067443877 @default.
- W2014716069 cites W2069351864 @default.
- W2014716069 cites W2070482948 @default.
- W2014716069 cites W2072106835 @default.
- W2014716069 cites W2073268517 @default.
- W2014716069 cites W2077341010 @default.
- W2014716069 cites W2077359776 @default.
- W2014716069 cites W2077950462 @default.
- W2014716069 cites W2078323710 @default.
- W2014716069 cites W2083159612 @default.
- W2014716069 cites W2084885369 @default.
- W2014716069 cites W2085525271 @default.
- W2014716069 cites W2085656281 @default.
- W2014716069 cites W2087161387 @default.
- W2014716069 cites W2092603991 @default.
- W2014716069 cites W2094304665 @default.
- W2014716069 cites W2102760479 @default.
- W2014716069 cites W2104852749 @default.
- W2014716069 cites W2108664872 @default.
- W2014716069 cites W2108700752 @default.
- W2014716069 cites W2110662884 @default.
- W2014716069 cites W2113333476 @default.
- W2014716069 cites W2115950845 @default.
- W2014716069 cites W2115960677 @default.
- W2014716069 cites W2128586767 @default.
- W2014716069 cites W2131860315 @default.
- W2014716069 cites W2144575277 @default.
- W2014716069 cites W2145158854 @default.
- W2014716069 cites W2149585679 @default.
- W2014716069 cites W2149591661 @default.
- W2014716069 cites W2151216008 @default.
- W2014716069 cites W2153312037 @default.
- W2014716069 cites W2155507662 @default.
- W2014716069 cites W2160284636 @default.
- W2014716069 cites W2166443483 @default.
- W2014716069 cites W2169288112 @default.
- W2014716069 cites W2315512556 @default.
- W2014716069 cites W26128403 @default.
- W2014716069 cites W30031754 @default.
- W2014716069 cites W4242123597 @default.
- W2014716069 doi "https://doi.org/10.1016/j.cellsig.2014.03.030" @default.
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