Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014716426> ?p ?o ?g. }
- W2014716426 endingPage "807" @default.
- W2014716426 startingPage "799" @default.
- W2014716426 abstract "The effect of continuous intrathecal infusion with morphine (5 μ/h) or naloxone (2 μ/h) was investigated with regard to analgesia and the apparent density of μ- and δ-opioid and neurokinin-I/substance P receptors in the rat spinal cord. Morphine infusion increased tail-flick and paw-pressure responses until day 4 after the mini-osmotic pump implant. A decline in antinociception, reflecting tolerance to morphine, was then apparent in both tests. Quantitative in vitro receptor autoradiography of [125I]FK-33824, [125I][d-Ala2]deltorphin-I and [125I] Bolton-Hunter substance P binding sites, as ligands of μ, δ and neurokinin-I/substance P receptors, respectively, was performed on lumbosacral spinal cord sections of seven-days tolerant animals. Treatments with morphine and naloxone induced a similar increase (37%) in the number of δ binding sites in the superficial laminae of the dorsal horn. In contrast, the density of μ-opioid receptors was only affected by naloxone (50% increase). Neurokinin-I/substance P binding parameters were not altered by these treatments. Thus, it appears that δ-opioid binding sites may be of special relevance with regard to the development of tolerance to opiates in the spinal cord." @default.
- W2014716426 created "2016-06-24" @default.
- W2014716426 creator A5016606343 @default.
- W2014716426 creator A5022172319 @default.
- W2014716426 creator A5025817854 @default.
- W2014716426 creator A5026942149 @default.
- W2014716426 creator A5055183128 @default.
- W2014716426 creator A5082842737 @default.
- W2014716426 date "1993-06-01" @default.
- W2014716426 modified "2023-10-16" @default.
- W2014716426 title "Opioid and substance p receptor adaptations in the rat spinal cord following sub-chronic intrathecal treatment with morphine and naloxone" @default.
- W2014716426 cites W1605641317 @default.
- W2014716426 cites W1841427327 @default.
- W2014716426 cites W1963615006 @default.
- W2014716426 cites W1966923957 @default.
- W2014716426 cites W1969753476 @default.
- W2014716426 cites W1986130864 @default.
- W2014716426 cites W1989723998 @default.
- W2014716426 cites W1990845463 @default.
- W2014716426 cites W1993477246 @default.
- W2014716426 cites W1997163051 @default.
- W2014716426 cites W1997179101 @default.
- W2014716426 cites W1998191034 @default.
- W2014716426 cites W2002092741 @default.
- W2014716426 cites W2009731699 @default.
- W2014716426 cites W2014849167 @default.
- W2014716426 cites W2017036944 @default.
- W2014716426 cites W2021208535 @default.
- W2014716426 cites W2023997081 @default.
- W2014716426 cites W2028833035 @default.
- W2014716426 cites W2032603698 @default.
- W2014716426 cites W2035065534 @default.
- W2014716426 cites W2041272952 @default.
- W2014716426 cites W2042636262 @default.
- W2014716426 cites W2044987726 @default.
- W2014716426 cites W2045015530 @default.
- W2014716426 cites W2050456195 @default.
- W2014716426 cites W2056423208 @default.
- W2014716426 cites W2058558193 @default.
- W2014716426 cites W2060606902 @default.
- W2014716426 cites W2062568898 @default.
- W2014716426 cites W2065968175 @default.
- W2014716426 cites W2072388030 @default.
- W2014716426 cites W2080908012 @default.
- W2014716426 cites W2081787537 @default.
- W2014716426 cites W2095410202 @default.
- W2014716426 cites W2112087382 @default.
- W2014716426 cites W2122569637 @default.
- W2014716426 cites W2171740240 @default.
- W2014716426 doi "https://doi.org/10.1016/0306-4522(93)90249-f" @default.
- W2014716426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7687333" @default.
- W2014716426 hasPublicationYear "1993" @default.
- W2014716426 type Work @default.
- W2014716426 sameAs 2014716426 @default.
- W2014716426 citedByCount "32" @default.
- W2014716426 crossrefType "journal-article" @default.
- W2014716426 hasAuthorship W2014716426A5016606343 @default.
- W2014716426 hasAuthorship W2014716426A5022172319 @default.
- W2014716426 hasAuthorship W2014716426A5025817854 @default.
- W2014716426 hasAuthorship W2014716426A5026942149 @default.
- W2014716426 hasAuthorship W2014716426A5055183128 @default.
- W2014716426 hasAuthorship W2014716426A5082842737 @default.
- W2014716426 hasConcept C118303440 @default.
- W2014716426 hasConcept C118552586 @default.
- W2014716426 hasConcept C126322002 @default.
- W2014716426 hasConcept C134018914 @default.
- W2014716426 hasConcept C170493617 @default.
- W2014716426 hasConcept C185592680 @default.
- W2014716426 hasConcept C2776533618 @default.
- W2014716426 hasConcept C2777389121 @default.
- W2014716426 hasConcept C2778750930 @default.
- W2014716426 hasConcept C2780775167 @default.
- W2014716426 hasConcept C2781063702 @default.
- W2014716426 hasConcept C42219234 @default.
- W2014716426 hasConcept C71924100 @default.
- W2014716426 hasConcept C98274493 @default.
- W2014716426 hasConceptScore W2014716426C118303440 @default.
- W2014716426 hasConceptScore W2014716426C118552586 @default.
- W2014716426 hasConceptScore W2014716426C126322002 @default.
- W2014716426 hasConceptScore W2014716426C134018914 @default.
- W2014716426 hasConceptScore W2014716426C170493617 @default.
- W2014716426 hasConceptScore W2014716426C185592680 @default.
- W2014716426 hasConceptScore W2014716426C2776533618 @default.
- W2014716426 hasConceptScore W2014716426C2777389121 @default.
- W2014716426 hasConceptScore W2014716426C2778750930 @default.
- W2014716426 hasConceptScore W2014716426C2780775167 @default.
- W2014716426 hasConceptScore W2014716426C2781063702 @default.
- W2014716426 hasConceptScore W2014716426C42219234 @default.
- W2014716426 hasConceptScore W2014716426C71924100 @default.
- W2014716426 hasConceptScore W2014716426C98274493 @default.
- W2014716426 hasIssue "3" @default.
- W2014716426 hasLocation W20147164261 @default.
- W2014716426 hasLocation W20147164262 @default.
- W2014716426 hasOpenAccess W2014716426 @default.
- W2014716426 hasPrimaryLocation W20147164261 @default.
- W2014716426 hasRelatedWork W1971852532 @default.
- W2014716426 hasRelatedWork W2034583712 @default.
- W2014716426 hasRelatedWork W2063619316 @default.