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• W2014716920 abstract "Cardiotoxicity is a serious side effect to treatment with 5-fluorouracil (5-FU), but the underlying mechanisms are not fully understood. The objective of this systematic review was to evaluate the pathophysiology of 5-FU- induced cardiotoxicity.We systematically searched PubMed for articles in English using the search terms: 5-FU OR 5-fluorouracil OR capecitabine AND cardiotoxicity. Papers evaluating the pathophysiology of this cardiotoxicity were included.We identified 27 articles of 26 studies concerning the pathophysiology of 5-FU-induced cardiotoxicity. The studies demonstrated 5-FU-induced: hemorrhagic infarction, interstitial fibrosis and inflammatory reaction in the myocardium; damage of the arterial endothelium followed by platelet aggregation; increased myocardial energy metabolism and depletion of high energy phosphate compounds; increased superoxide anion levels and a reduced antioxidant capacity; vasoconstriction of arteries; changes in red blood cell (RBC) structure, function and metabolism; alterations in plasma levels of substances involved in coagulation and fibrinolysis and increased endothelin-1 levels and N-terminal-pro brain natriuretic peptide levels. Based on these findings the proposed mechanisms are: endothelial injury followed by thrombosis, increased metabolism leading to energy depletion and ischemia, oxidative stress causing cellular damage, coronary artery spasm leading to myocardial ischemia and diminished ability of RBCs to transfer oxygen resulting in myocardial ischemia.There is no evidence for a single mechanism responsible for 5-FU-induced cardiotoxicity, and the underlying mechanisms might be multifactorial. Further research is needed to elucidate the pathogenesis of this side effect." @default.
• W2014716920 created "2016-06-24" @default.
• W2014716920 creator A5008030999 @default.
• W2014716920 creator A5008068706 @default.
• W2014716920 creator A5065167754 @default.
• W2014716920 creator A5090876784 @default.
• W2014716920 date "2014-09-04" @default.
• W2014716920 modified "2023-10-14" @default.
• W2014716920 title "A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity" @default.
• W2014716920 cites W1964839077 @default.
• W2014716920 cites W1972189746 @default.
• W2014716920 cites W1973136410 @default.
• W2014716920 cites W1975266720 @default.
• W2014716920 cites W1989753015 @default.
• W2014716920 cites W1990058181 @default.
• W2014716920 cites W1993213432 @default.
• W2014716920 cites W1994088489 @default.
• W2014716920 cites W1996582703 @default.
• W2014716920 cites W1998910446 @default.
• W2014716920 cites W1999217768 @default.
• W2014716920 cites W1999226972 @default.
• W2014716920 cites W2002343899 @default.
• W2014716920 cites W2002977408 @default.
• W2014716920 cites W2004831103 @default.
• W2014716920 cites W2009262960 @default.
• W2014716920 cites W2009471094 @default.
• W2014716920 cites W2019096594 @default.
• W2014716920 cites W2020934562 @default.
• W2014716920 cites W2023929921 @default.
• W2014716920 cites W2025760994 @default.
• W2014716920 cites W2025865627 @default.
• W2014716920 cites W2027123057 @default.
• W2014716920 cites W2027544367 @default.
• W2014716920 cites W2036225919 @default.
• W2014716920 cites W2056932031 @default.
• W2014716920 cites W2062676382 @default.
• W2014716920 cites W2073947187 @default.
• W2014716920 cites W2074318769 @default.
• W2014716920 cites W2079316416 @default.
• W2014716920 cites W2079327708 @default.
• W2014716920 cites W2079709100 @default.
• W2014716920 cites W2080335794 @default.
• W2014716920 cites W2080941417 @default.
• W2014716920 cites W2082217893 @default.
• W2014716920 cites W2083877653 @default.
• W2014716920 cites W2085825922 @default.
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• W2014716920 cites W2093422837 @default.
• W2014716920 cites W2093823863 @default.
• W2014716920 cites W2093864907 @default.
• W2014716920 cites W2095241287 @default.
• W2014716920 cites W2095613864 @default.
• W2014716920 cites W2095859714 @default.
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• W2014716920 doi "https://doi.org/10.1186/2050-6511-15-47" @default.
• W2014716920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4170068" @default.
• W2014716920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25186061" @default.
• W2014716920 hasPublicationYear "2014" @default.
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