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- W2014718130 abstract "5′-Deoxy-5′-methylthioadenosine inhibits Concanavalin A induced rat T lymphocyte proliferation in a dose dependent manner (50 μM to 1000 μM). The extent of inhibition by MTA of lymphocyte proliferation was greatest when MTA was added to the cells at the same time as Concanavalin A. The determination of cyclic AMP level from 30 min to the 6th hour shows that 5′-Deoxy-5′-methylthioadenosine inhibition is correlated with an elevation of cyclic AMP at this mitogen recognition phase. 5′-Deoxy-5′-methylthioadenosine concentrations that inhibit rat T lymphocyte proliferation also inhibit phosphodiesterase activity. This biochemical mechanism could be specific to 5′-Deoxy-5′-methylthioadenosine inhibition since in an another model of inhibition of rat T lymphocyte proliferation (2′-Deoxyadenosine 10 μM, in adenosine deaminase deficiency conditions : 2′-Deoxycoformycin 10 μM), no significant modification of cyclic AMP level can be demonstrated." @default.
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- W2014718130 date "1983-06-01" @default.
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- W2014718130 title "5′-Deoxy-5′-methylthioadenosine inhibition of rat T lymphocyte phosphodiesterase : Correlation with inhibition of Con A induced proliferation" @default.
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- W2014718130 doi "https://doi.org/10.1016/0006-291x(83)91743-6" @default.
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