Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014718329> ?p ?o ?g. }
- W2014718329 endingPage "2001" @default.
- W2014718329 startingPage "1991" @default.
- W2014718329 abstract "The Drosophila body axes are established in the oocyte during oogenesis. Oocyte polarization is initiated by Gurken, which signals from the germline through the epidermal growth factor receptor (Egfr) to the posterior follicle cells (PFCs). In response the PFCs generate an unidentified polarizing signal that regulates oocyte polarity. We have identified a loss-of-function mutation of flapwing, which encodes the catalytic subunit of Protein Phosphatase 1β (PP1β) that disrupts oocyte polarization. We show that PP1β, by regulating myosin activity, controls the generation of the polarizing signal. Excessive myosin activity in the PFCs causes oocyte mispolarization and defective Notch signaling and endocytosis in the PFCs. The integrated activation of JAK/STAT and Egfr signaling results in the sensitivity of PFCs to defective Notch. Interestingly, our results also demonstrate a role of PP1β in generating the polarizing signal independently of Notch, indicating a direct involvement of somatic myosin activity in axis formation." @default.
- W2014718329 created "2016-06-24" @default.
- W2014718329 creator A5044406095 @default.
- W2014718329 creator A5048411184 @default.
- W2014718329 creator A5049503424 @default.
- W2014718329 creator A5067668992 @default.
- W2014718329 date "2011-05-15" @default.
- W2014718329 modified "2023-10-14" @default.
- W2014718329 title "Regulation of somatic myosin activity by Protein Phosphatase 1β controls <i>Drosophila</i> oocyte polarization" @default.
- W2014718329 cites W1568494138 @default.
- W2014718329 cites W1855259954 @default.
- W2014718329 cites W1964232557 @default.
- W2014718329 cites W1965066532 @default.
- W2014718329 cites W1966870837 @default.
- W2014718329 cites W1967532512 @default.
- W2014718329 cites W1982726261 @default.
- W2014718329 cites W1988367343 @default.
- W2014718329 cites W1990045619 @default.
- W2014718329 cites W1994663160 @default.
- W2014718329 cites W1996034566 @default.
- W2014718329 cites W1997087774 @default.
- W2014718329 cites W1999751317 @default.
- W2014718329 cites W2003460583 @default.
- W2014718329 cites W2005966470 @default.
- W2014718329 cites W2006229889 @default.
- W2014718329 cites W2009747268 @default.
- W2014718329 cites W2012400405 @default.
- W2014718329 cites W2016913573 @default.
- W2014718329 cites W2017995506 @default.
- W2014718329 cites W2023100673 @default.
- W2014718329 cites W2027128159 @default.
- W2014718329 cites W2029650615 @default.
- W2014718329 cites W2029856261 @default.
- W2014718329 cites W2032295238 @default.
- W2014718329 cites W2034341872 @default.
- W2014718329 cites W2054041407 @default.
- W2014718329 cites W2057989418 @default.
- W2014718329 cites W2058693333 @default.
- W2014718329 cites W2061212583 @default.
- W2014718329 cites W2077083517 @default.
- W2014718329 cites W2078530446 @default.
- W2014718329 cites W2078657639 @default.
- W2014718329 cites W2081580757 @default.
- W2014718329 cites W2082362642 @default.
- W2014718329 cites W2096658690 @default.
- W2014718329 cites W2110117704 @default.
- W2014718329 cites W2112310659 @default.
- W2014718329 cites W2118642448 @default.
- W2014718329 cites W2125545718 @default.
- W2014718329 cites W2128573075 @default.
- W2014718329 cites W2133943800 @default.
- W2014718329 cites W2135685454 @default.
- W2014718329 cites W2144792264 @default.
- W2014718329 cites W2145232323 @default.
- W2014718329 cites W2150541721 @default.
- W2014718329 cites W2151418659 @default.
- W2014718329 cites W2152018084 @default.
- W2014718329 cites W2153368569 @default.
- W2014718329 cites W2159207718 @default.
- W2014718329 cites W2160369364 @default.
- W2014718329 cites W2184390227 @default.
- W2014718329 cites W2185119839 @default.
- W2014718329 cites W4297673475 @default.
- W2014718329 doi "https://doi.org/10.1242/dev.062190" @default.
- W2014718329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3082304" @default.
- W2014718329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21490061" @default.
- W2014718329 hasPublicationYear "2011" @default.
- W2014718329 type Work @default.
- W2014718329 sameAs 2014718329 @default.
- W2014718329 citedByCount "25" @default.
- W2014718329 countsByYear W20147183292012 @default.
- W2014718329 countsByYear W20147183292013 @default.
- W2014718329 countsByYear W20147183292014 @default.
- W2014718329 countsByYear W20147183292016 @default.
- W2014718329 countsByYear W20147183292017 @default.
- W2014718329 countsByYear W20147183292018 @default.
- W2014718329 countsByYear W20147183292019 @default.
- W2014718329 countsByYear W20147183292020 @default.
- W2014718329 countsByYear W20147183292021 @default.
- W2014718329 countsByYear W20147183292022 @default.
- W2014718329 countsByYear W20147183292023 @default.
- W2014718329 crossrefType "journal-article" @default.
- W2014718329 hasAuthorship W2014718329A5044406095 @default.
- W2014718329 hasAuthorship W2014718329A5048411184 @default.
- W2014718329 hasAuthorship W2014718329A5049503424 @default.
- W2014718329 hasAuthorship W2014718329A5067668992 @default.
- W2014718329 hasBestOaLocation W20147183292 @default.
- W2014718329 hasConcept C104317684 @default.
- W2014718329 hasConcept C109825262 @default.
- W2014718329 hasConcept C11960822 @default.
- W2014718329 hasConcept C134305767 @default.
- W2014718329 hasConcept C178666793 @default.
- W2014718329 hasConcept C196843134 @default.
- W2014718329 hasConcept C2776690073 @default.
- W2014718329 hasConcept C54355233 @default.
- W2014718329 hasConcept C62478195 @default.
- W2014718329 hasConcept C6997183 @default.
- W2014718329 hasConcept C86803240 @default.