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• W2014718392 abstract "The transcription factors C/EBPalpha and Sp1 functionally interact to induce expression of specific genes during myeloid and epithelial cell differentiation. The C/EBPalpha-Sp1 transcription factor module binds to enhancer elements within the upstream regulatory sequences of target genes. In our previous study we identified mouse TPA inducible sequence 7 (TIS7) as a novel co-repressor in epithelial cells undergoing loss of polarity. Increased levels of TIS7 down-regulate the transcription of a specific set of genes. Using bioinformatic analysis we identified a common binding site for the C/EBPalpha-Spl transcription factor module within the upstream regulatory regions of TIS7-regulated genes. The inhibitory effect of TIS7 on C/EBPalpha-Sp1-mediated transcription was confirmed by reporter assays. Our data showed that the TIS7 effect was mediated through specific interference with Sp1 transcriptional activity. Furthermore, TIS7 prevented formation of a complex between Sp1 protein and its consensus DNA binding site. Data presented here further specify the mechanism of action of the transcriptional co-repressor TIS7 as well as document the strength of a bioinformatic approach for the prediction and analysis of transcription factor modules." @default.
• W2014718392 created "2016-06-24" @default.
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• W2014718392 date "2004-02-01" @default.
• W2014718392 modified "2023-10-14" @default.
• W2014718392 title "Inhibitory Effect of TIS7 on Sp1-C/EBPα Transcription Factor Module Activity" @default.
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• W2014718392 doi "https://doi.org/10.1016/j.jmb.2003.11.060" @default.
• W2014718392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15095974" @default.
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