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• W2014719893 abstract "Objective: Our study aimed to determine the hemodynamic mechanisms through which cigarette smoking, as an independent risk factor, induces erectile dysfunction (ED). Design: Prospective study. Materials/Methods: We conducted a standard ED evaluation that included history, physical exam, serum glucose, testosterone, and prolactin levels. We then excluded ED patients with abnormal androgen profile, and patients with ED risk factors other than smoking. A total of 79 ED patients entered the study including 41 current smokers and 38 never smokers. All patients then underwent extensive evaluation, including nocturnal penile tumescence (NPT) monitoring using Rigiscan, followed by intracavernosal pharmaco-testing (ICP) with Trimix, pharmaco-penile duplex ultrasonography (PPDU), and re-dosing pharmaco-cavernosometry (RPC). Results of the above tests were compared in the smoker and non-smoker groups. We also performed receiver operator characteristic curve (ROC) analysis to determine which diagnostic parameter is most affected by cigarette smoking. Results: The average age for smokers and non-smokers was 44.3 and 40.2 years respectively (p = 0.08). 17% of smokers and 42% of non-smokers developed rigid erections in response to ICP. 24% of smokers had normal NPT testing compared to 45% of non-smokers (p = 0.02). The average peak systolic velocity (PSV) was 26.8 and 31 cm/sec for smokers and non-smokers respectively (p = 0.19). On performing RPC, an abnormal maintenance flow (MF) of >5 ml/min was detected in 78% of smokers and in 47% of non-smokers (p = 0.005). Using smoking as the outcome, the ROC area of different diagnostic parameters was as follows: 0.76 for penile base rigidity, 0.58 for PSV, and 0.71 for MF. Conclusions: The results of ICP and NPT testing in our smoker and non-smoker groups indicate that ED in smokers is mainly due to organic etiology. Also, our ICP results indicate that smoking negatively affects the response to intracavernosal injections. Based on the PPDU findings, and the higher incidence of abnormal MF in the smoker group and its relatively high ROC value, we conclude that ED in smokers is mainly due to involvement of the penile veno-occlusive mechanisms." @default.
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• W2014719893 date "2001-09-01" @default.
• W2014719893 modified "2023-09-26" @default.
• W2014719893 title "Cigarette smoking: penile hemodynamic changes resulting in erectile dysfunction." @default.
• W2014719893 doi "https://doi.org/10.1016/s0015-0282(01)02772-8" @default.
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