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- W2014721575 abstract "The amyloid-β (Aβ) peptide (1–42) aggregation into oligomeric and fibrillar species affects neuronal viability, having a causal role in the development of Alzheimer's disease. Among dietary anthocyanins, cyanidin 3-O-glucoside (Cy-3G) and its metabolites, such as protocatechuic acid (PA), have gained attention as potential neuroprotective agents. In this in-vitro study, we demonstrated that Cy-3G, but not PA, can inhibit Aβ1–42 spontaneous aggregation using thioflavin T fluorescence assay and transmission electron microscopy. Furthermore, treatment of human neuronal SH-SY5Y cells with Cy-3G during oligomeric and fibrillar Aβ1−42 treatment prevents neuronal viability loss. These protective effects were still evident when Cy-3G treatment was initiated after the appearance of oligomeric Aβ1−42 neurotoxicity. Taken together, these results suggest that Cy-3G may protect and rescue the neuronal cells from toxicity induced by Aβ1−42." @default.
- W2014721575 created "2016-06-24" @default.
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- W2014721575 date "2008-10-08" @default.
- W2014721575 modified "2023-09-30" @default.
- W2014721575 title "Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity" @default.
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- W2014721575 doi "https://doi.org/10.1097/wnr.0b013e32830fe4b8" @default.
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