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• W2014722859 abstract "The TAR DNA-binding protein-43 (TDP-43) has been identified as a major constituent of inclusions found in frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). To determine a possible role for TDP-43 in Alzheimer's disease (AD), a site-directed caspase-cleavage antibody to TDP-43 based upon a known caspase-3 cleavage consensus site within TDP- 43 at position D219 was designed. In vitro, this antibody labeled the predicted 25 kDa caspase-cleavage fragment of TDP-43 without labeling full-length TDP-43 following digestion of recombinant TDP-43 with caspase-3 or treatment of HeLa cells with staurosporine. Application of this antibody in postmortem brain sections indicated the presence of caspase-cleaved TDP-43 in Hirano bodies, tangles, reactive astrocytes and neuritic plaques of the AD brain. Caspase-cleaved TDP-43 also co-localized with ubiquitin labeled neurons as well as dystrophic neurites within plaque regions. These results suggest that caspase-cleaved TDP-43 is a major pathological finding in AD and may contribute to the neurodegeneration associated with this disease." @default.
• W2014722859 created "2016-06-24" @default.
• W2014722859 creator A5042512732 @default.
• W2014722859 date "2008-09-01" @default.
• W2014722859 modified "2023-10-05" @default.
• W2014722859 title "Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease" @default.
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• W2014722859 doi "https://doi.org/10.1016/j.brainres.2008.06.094" @default.
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