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- W2014723193 abstract "Tumor protein (TP)-p53 family members (TP63, TP63 and TP73) are guardians of the genome and key players in orchestrating the cellular response to cisplatin treatment. Cisplatin-induced phosphorylation of ΔNp63α was shown to have a role in regulating intracellular ΔNp63α protein levels. We previously found that squamous cell carcinoma (SCC) cells exposed to cisplatin displayed the ATM-dependent phosphorylation of ΔNp63α (p-ΔNp63α), which is critical for the transcriptional regulation of specific downstream mRNAs and microRNAs and is likely to underlie the chemoresistance of SCC cells. However, SCC cells expressing non-p-ΔNp63α became more cisplatin-resistant. We also found that p-ΔNp63α forms complexes with a number of proteins involved in cell death response through regulation of cell cycle arrest, apoptosis, autophagy, RNA splicing and chromatin modifications. Here, we showed that p-ΔNp63α induced ARG1, GAPDH, and CPT2 gene transcription in cisplatin-sensitive SCC cells, while non-p-ΔNp63α increased a transcription of CAD, G6PD and FASN genes in cisplatin-resistant SCC cells. We report that the p-ΔNp63α-dependent regulatory mechanisms implicated in the modulation of plethora of pathways, including amino acid, carbohydrate, lipid and nucleotide metabolisms, thereby affect tumor cell response to cisplatin-induced cell death, suggesting that the ATM-dependent ΔNp63α pathway plays a role in the resistance of tumor cells to platinum therapy." @default.
- W2014723193 created "2016-06-24" @default.
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- W2014723193 creator A5033574471 @default.
- W2014723193 creator A5048533064 @default.
- W2014723193 creator A5049932698 @default.
- W2014723193 date "2012-09-05" @default.
- W2014723193 modified "2023-09-26" @default.
- W2014723193 title "Phospho-ΔNp63α/SREBF1 protein interactions: Bridging cell metabolism and cisplatin chemoresistance" @default.
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- W2014723193 doi "https://doi.org/10.4161/cc.22022" @default.
- W2014723193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3495824" @default.
- W2014723193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22951905" @default.
- W2014723193 hasPublicationYear "2012" @default.