FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014724304> ?p ?o ?g. }

• W2014724304 endingPage "153" @default.
• W2014724304 startingPage "138" @default.
• W2014724304 abstract "In animal species and humans, artesunate (AS) undergoes extensive and complex biotransformation to an active metabolite, dihydroartemisinin (DHA). The bioequivalence of two intravenous AS pharmaceutical products with 5% NaHCO3 (China Formulation) or 0.3 M PBS (WRAIR Formulation) was determined in rats in a two-formulation, two-period, and two-sequence crossover experimental design. Following single and multiple intravenous administrations, a series of blood samples was collected by using an automated blood sampler and drug concentrations were analyzed by LC-MS/MS. The 90% CI of the difference between the two intravenous formulations was contained within 80–125% of the geometric mean of pharmacokinetic parameters for AS and DHA in all animals dosed. Hematological effects were studied on days 1 and 3 after the final dosing, and a rapidly reversible hematological toxicity (significant reductions in reticulocyte levels) was seen in the peripheral blood of the rats treated with each formulation. The results showed that bioequivalence with the parent compound and active metabolite was fulfilled in the 82.3–117.7% ranges of all parameters (AUC0–t, Cmax, concentration average and degree of fluctuation) in the two-period and two-sequence crossover studies following single and repeated intravenous injections. For the metabolite, the equivalence was satisfied in most pharmacokinetic parameters tested due to the variability in the hydrolysis rate of AS to DHA. The WRAIR formulation of AS was considered to be bioequivalent to the Chinese formulation at steady-state according to the total drug exposure, in terms of both parent drug and active metabolite, rapidly reversal in reticulocyte decline, and extension of single and multiple administrations. Therefore, the parent drug and active metabolites should play similar important roles in the determination of efficacy and safety of the drug." @default.
• W2014724304 created "2016-06-24" @default.
• W2014724304 creator A5046891485 @default.
• W2014724304 creator A5055732602 @default.
• W2014724304 creator A5057673321 @default.
• W2014724304 creator A5076175383 @default.
• W2014724304 date "2011-01-07" @default.
• W2014724304 modified "2023-09-26" @default.
• W2014724304 title "Bioequivalence of Two Intravenous Artesunate Products with Its Active Metabolite Following Single and Multiple Injections" @default.
• W2014724304 cites W1550518551 @default.
• W2014724304 cites W1902021372 @default.
• W2014724304 cites W1964860455 @default.
• W2014724304 cites W1979554655 @default.
• W2014724304 cites W1985659975 @default.
• W2014724304 cites W1987115509 @default.
• W2014724304 cites W1989897941 @default.
• W2014724304 cites W1991072114 @default.
• W2014724304 cites W2007854330 @default.
• W2014724304 cites W201679802 @default.
• W2014724304 cites W2024144574 @default.
• W2014724304 cites W2034496445 @default.
• W2014724304 cites W2046007360 @default.
• W2014724304 cites W2046445824 @default.
• W2014724304 cites W2055357818 @default.
• W2014724304 cites W2055659067 @default.
• W2014724304 cites W2058140944 @default.
• W2014724304 cites W2063725332 @default.
• W2014724304 cites W2079205934 @default.
• W2014724304 cites W2084683758 @default.
• W2014724304 cites W2102174959 @default.
• W2014724304 cites W2108209076 @default.
• W2014724304 cites W2123640851 @default.
• W2014724304 cites W2144789366 @default.
• W2014724304 cites W2161506676 @default.
• W2014724304 cites W2166363384 @default.
• W2014724304 cites W2182553675 @default.
• W2014724304 cites W2413755247 @default.
• W2014724304 doi "https://doi.org/10.3390/ph4010138" @default.
• W2014724304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4052546" @default.
• W2014724304 hasPublicationYear "2011" @default.
• W2014724304 type Work @default.
• W2014724304 sameAs 2014724304 @default.
• W2014724304 citedByCount "1" @default.
• W2014724304 countsByYear W20147243042021 @default.
• W2014724304 crossrefType "journal-article" @default.
• W2014724304 hasAuthorship W2014724304A5046891485 @default.
• W2014724304 hasAuthorship W2014724304A5055732602 @default.
• W2014724304 hasAuthorship W2014724304A5057673321 @default.
• W2014724304 hasAuthorship W2014724304A5076175383 @default.
• W2014724304 hasBestOaLocation W20147243041 @default.
• W2014724304 hasConcept C112705442 @default.
• W2014724304 hasConcept C126322002 @default.
• W2014724304 hasConcept C142724271 @default.
• W2014724304 hasConcept C149151106 @default.
• W2014724304 hasConcept C181389837 @default.
• W2014724304 hasConcept C203014093 @default.
• W2014724304 hasConcept C204787440 @default.
• W2014724304 hasConcept C22979827 @default.
• W2014724304 hasConcept C27081682 @default.
• W2014724304 hasConcept C2776120307 @default.
• W2014724304 hasConcept C2777288759 @default.
• W2014724304 hasConcept C2777477808 @default.
• W2014724304 hasConcept C2778048844 @default.
• W2014724304 hasConcept C2778059366 @default.
• W2014724304 hasConcept C2778371730 @default.
• W2014724304 hasConcept C2781160685 @default.
• W2014724304 hasConcept C42404028 @default.
• W2014724304 hasConcept C71924100 @default.
• W2014724304 hasConcept C87813604 @default.
• W2014724304 hasConcept C98274493 @default.
• W2014724304 hasConceptScore W2014724304C112705442 @default.
• W2014724304 hasConceptScore W2014724304C126322002 @default.
• W2014724304 hasConceptScore W2014724304C142724271 @default.
• W2014724304 hasConceptScore W2014724304C149151106 @default.
• W2014724304 hasConceptScore W2014724304C181389837 @default.
• W2014724304 hasConceptScore W2014724304C203014093 @default.
• W2014724304 hasConceptScore W2014724304C204787440 @default.
• W2014724304 hasConceptScore W2014724304C22979827 @default.
• W2014724304 hasConceptScore W2014724304C27081682 @default.
• W2014724304 hasConceptScore W2014724304C2776120307 @default.
• W2014724304 hasConceptScore W2014724304C2777288759 @default.
• W2014724304 hasConceptScore W2014724304C2777477808 @default.
• W2014724304 hasConceptScore W2014724304C2778048844 @default.
• W2014724304 hasConceptScore W2014724304C2778059366 @default.
• W2014724304 hasConceptScore W2014724304C2778371730 @default.
• W2014724304 hasConceptScore W2014724304C2781160685 @default.
• W2014724304 hasConceptScore W2014724304C42404028 @default.
• W2014724304 hasConceptScore W2014724304C71924100 @default.
• W2014724304 hasConceptScore W2014724304C87813604 @default.
• W2014724304 hasConceptScore W2014724304C98274493 @default.
• W2014724304 hasIssue "1" @default.
• W2014724304 hasLocation W20147243041 @default.
• W2014724304 hasLocation W20147243042 @default.
• W2014724304 hasOpenAccess W2014724304 @default.
• W2014724304 hasPrimaryLocation W20147243041 @default.
• W2014724304 hasRelatedWork W1998356222 @default.
• W2014724304 hasRelatedWork W2003476460 @default.
• W2014724304 hasRelatedWork W2011337719 @default.

• next