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• W2014727568 abstract "The correlation between changes in cytosolic Ca2+ levels ([Ca2+]i) and the release of vascular relaxing factor(s) was investigated in the endothelium of rabbit aortic valve. ATP, carbachol and thapsigargin increased endothelial [Ca2+]i in rabbit aortic valve loaded with a leakage resistant, fluorescent Ca2+ indicator, fura-PE3. Release of relaxing factors was bioassayed using the 'sandwich' preparation in which contraction was measured in the endothelium-denuded rabbit aorta attached to the endothelial surface of the valve. Addition of ATP, carbachol and thapsigargin induced sustained relaxation of the phenylephrine-induced contraction of the aorta in the 'sandwich' preparation. N(G)-monomethyl-L-arginine (L-NMMA) greatly attenuated the relaxation induced by carbachol, and combined treatment with tetra-n-butylammonium completely inhibited the relaxation. These results suggest that the endothelial relaxing factors released from aortic valve are nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). When the increase in endothelial [Ca2+]i was plotted against the relaxation, the carbachol-induced increase in [Ca2+]i elicited greater relaxation than did ATP or thapsigargin at a given [Ca2+]i. This suggests that various agonists differently modulate the relationship between [Ca2+]i and release of NO." @default.
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• W2014727568 title "Agonist-dependent difference in the relationship between cytosolic Ca2+ level and release of vascular relaxing factors in the endothelium of rabbit aortic valve" @default.
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• W2014727568 doi "https://doi.org/10.1016/s0014-2999(98)00913-3" @default.
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