Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014727711> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2014727711 endingPage "367" @default.
- W2014727711 startingPage "361" @default.
- W2014727711 abstract "Interleukin-5 (IL-5), which is produced primarily by type 2 T helper lymphocytes (Th2), is an eosinophil differentiation and activation factor. Increased numbers of eosinophils in peripherial blood or tissues (eosinophilia) are observed in asthmatic human patients, in animals with helminth infections, and in dogs with allergic diseases. Antagonism of IL-5 activity is being explored as a potential treatment of a number of disease conditions associated with eosinophils in animal models. In order to study the expression and function of this cytokine in the dog, we have isolated and characterized the canine IL-5 gene. The canine IL-5 polypeptide deduced from the cDNA is composed of 134 amino acids that share varying degrees of homology with IL-5 isolated from several mammals. The genomic structure of the canine IL-5 gene consists of four exons and three introns in the coding region, similar to that of the previously characterized human and mouse IL-5 genes. Recombinant canine IL-5 protein, expressed in Pichia pastoris, is biologically active in a cell proliferation assay. Canine IL-5 gene sequences and the biologically active protein described in this study will be useful reagents for future studies of this cytokine in physiologic processes and in pathologic conditions of the dog." @default.
- W2014727711 created "2016-06-24" @default.
- W2014727711 creator A5001699296 @default.
- W2014727711 creator A5019753851 @default.
- W2014727711 creator A5067164709 @default.
- W2014727711 creator A5085565014 @default.
- W2014727711 date "2001-06-01" @default.
- W2014727711 modified "2023-10-16" @default.
- W2014727711 title "Canine Interleukin-5: Molecular Characterization of the Gene and Expression of Biologically Active Recombinant Protein" @default.
- W2014727711 cites W1519148488 @default.
- W2014727711 cites W1599338889 @default.
- W2014727711 cites W1970854796 @default.
- W2014727711 cites W1972821066 @default.
- W2014727711 cites W1986197230 @default.
- W2014727711 cites W1989440719 @default.
- W2014727711 cites W1990816025 @default.
- W2014727711 cites W1991104975 @default.
- W2014727711 cites W1998320002 @default.
- W2014727711 cites W2009081607 @default.
- W2014727711 cites W2033682428 @default.
- W2014727711 cites W2047328650 @default.
- W2014727711 cites W2071758596 @default.
- W2014727711 cites W2102365260 @default.
- W2014727711 cites W2109554295 @default.
- W2014727711 cites W2114194173 @default.
- W2014727711 cites W2123846748 @default.
- W2014727711 cites W2136902889 @default.
- W2014727711 cites W2140686309 @default.
- W2014727711 cites W2157245557 @default.
- W2014727711 cites W2160026156 @default.
- W2014727711 cites W2161045200 @default.
- W2014727711 doi "https://doi.org/10.1089/107999001750277835" @default.
- W2014727711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11440633" @default.
- W2014727711 hasPublicationYear "2001" @default.
- W2014727711 type Work @default.
- W2014727711 sameAs 2014727711 @default.
- W2014727711 citedByCount "4" @default.
- W2014727711 countsByYear W20147277112014 @default.
- W2014727711 crossrefType "journal-article" @default.
- W2014727711 hasAuthorship W2014727711A5001699296 @default.
- W2014727711 hasAuthorship W2014727711A5019753851 @default.
- W2014727711 hasAuthorship W2014727711A5067164709 @default.
- W2014727711 hasAuthorship W2014727711A5085565014 @default.
- W2014727711 hasConcept C104317684 @default.
- W2014727711 hasConcept C150194340 @default.
- W2014727711 hasConcept C153911025 @default.
- W2014727711 hasConcept C165525559 @default.
- W2014727711 hasConcept C181901479 @default.
- W2014727711 hasConcept C187882448 @default.
- W2014727711 hasConcept C203014093 @default.
- W2014727711 hasConcept C2776042228 @default.
- W2014727711 hasConcept C2777037409 @default.
- W2014727711 hasConcept C2778690821 @default.
- W2014727711 hasConcept C2781372317 @default.
- W2014727711 hasConcept C36823959 @default.
- W2014727711 hasConcept C40767141 @default.
- W2014727711 hasConcept C54355233 @default.
- W2014727711 hasConcept C74172505 @default.
- W2014727711 hasConcept C86803240 @default.
- W2014727711 hasConceptScore W2014727711C104317684 @default.
- W2014727711 hasConceptScore W2014727711C150194340 @default.
- W2014727711 hasConceptScore W2014727711C153911025 @default.
- W2014727711 hasConceptScore W2014727711C165525559 @default.
- W2014727711 hasConceptScore W2014727711C181901479 @default.
- W2014727711 hasConceptScore W2014727711C187882448 @default.
- W2014727711 hasConceptScore W2014727711C203014093 @default.
- W2014727711 hasConceptScore W2014727711C2776042228 @default.
- W2014727711 hasConceptScore W2014727711C2777037409 @default.
- W2014727711 hasConceptScore W2014727711C2778690821 @default.
- W2014727711 hasConceptScore W2014727711C2781372317 @default.
- W2014727711 hasConceptScore W2014727711C36823959 @default.
- W2014727711 hasConceptScore W2014727711C40767141 @default.
- W2014727711 hasConceptScore W2014727711C54355233 @default.
- W2014727711 hasConceptScore W2014727711C74172505 @default.
- W2014727711 hasConceptScore W2014727711C86803240 @default.
- W2014727711 hasIssue "6" @default.
- W2014727711 hasLocation W20147277111 @default.
- W2014727711 hasLocation W20147277112 @default.
- W2014727711 hasOpenAccess W2014727711 @default.
- W2014727711 hasPrimaryLocation W20147277111 @default.
- W2014727711 hasRelatedWork W130457388 @default.
- W2014727711 hasRelatedWork W1965990385 @default.
- W2014727711 hasRelatedWork W2020643736 @default.
- W2014727711 hasRelatedWork W2021084899 @default.
- W2014727711 hasRelatedWork W2056172754 @default.
- W2014727711 hasRelatedWork W2083958575 @default.
- W2014727711 hasRelatedWork W2250033156 @default.
- W2014727711 hasRelatedWork W2347635724 @default.
- W2014727711 hasRelatedWork W2393170758 @default.
- W2014727711 hasRelatedWork W2808675497 @default.
- W2014727711 hasVolume "21" @default.
- W2014727711 isParatext "false" @default.
- W2014727711 isRetracted "false" @default.
- W2014727711 magId "2014727711" @default.
- W2014727711 workType "article" @default.