Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014727866> ?p ?o ?g. }
- W2014727866 endingPage "e54934" @default.
- W2014727866 startingPage "e54934" @default.
- W2014727866 abstract "Piscirickettsia salmonis is a fish bacterial pathogen that has severely challenged the sustainability of the Chilean salmon industry since its appearance in 1989. As this Gram-negative bacterium has been poorly characterized, relevant aspects of its life cycle, virulence and pathogenesis must be identified in order to properly design prophylactic procedures. This report provides evidence of the functional presence in P. salmonis of four genes homologous to those described for Dot/Icm Type IV Secretion Systems. The Dot/Icm System, the major virulence mechanism of phylogenetically related pathogens Legionella pneumophila and Coxiella burnetii, is responsible for their intracellular survival and multiplication, conditions that may also apply to P. salmonis. Our results demonstrate that the four P. salmonis dot/icm homologues (dotB, dotA, icmK and icmE) are expressed both during in vitro tissue culture cells infection and growing in cell-free media, suggestive of their putative constitutive expression. Additionally, as it happens in other referential bacterial systems, temporal acidification of cell-free media results in over expression of all four P. salmonis genes, a well-known strategy by which SSTIV-containing bacteria inhibit phagosome-lysosome fusion to survive. These findings are very important to understand the virulence mechanisms of P. salmonis in order to design new prophylactic alternatives to control the disease." @default.
- W2014727866 created "2016-06-24" @default.
- W2014727866 creator A5004434870 @default.
- W2014727866 creator A5023772384 @default.
- W2014727866 creator A5035482159 @default.
- W2014727866 creator A5062680029 @default.
- W2014727866 creator A5076305949 @default.
- W2014727866 creator A5089228213 @default.
- W2014727866 date "2013-01-28" @default.
- W2014727866 modified "2023-10-06" @default.
- W2014727866 title "Evidence of the Presence of a Functional Dot/Icm Type IV-B Secretion System in the Fish Bacterial Pathogen Piscirickettsia salmonis" @default.
- W2014727866 cites W1583167973 @default.
- W2014727866 cites W1785960922 @default.
- W2014727866 cites W1869262429 @default.
- W2014727866 cites W1914922901 @default.
- W2014727866 cites W1920928767 @default.
- W2014727866 cites W1978100320 @default.
- W2014727866 cites W1988942882 @default.
- W2014727866 cites W1991671300 @default.
- W2014727866 cites W2006463424 @default.
- W2014727866 cites W2006779057 @default.
- W2014727866 cites W2010009494 @default.
- W2014727866 cites W2012562110 @default.
- W2014727866 cites W2020889689 @default.
- W2014727866 cites W2021784000 @default.
- W2014727866 cites W2023879960 @default.
- W2014727866 cites W2028764779 @default.
- W2014727866 cites W2031203548 @default.
- W2014727866 cites W2041548140 @default.
- W2014727866 cites W2043238044 @default.
- W2014727866 cites W2047131965 @default.
- W2014727866 cites W2047841570 @default.
- W2014727866 cites W2050204065 @default.
- W2014727866 cites W2051599601 @default.
- W2014727866 cites W2060371733 @default.
- W2014727866 cites W2067629725 @default.
- W2014727866 cites W2067685740 @default.
- W2014727866 cites W2078712188 @default.
- W2014727866 cites W2078921017 @default.
- W2014727866 cites W2080645004 @default.
- W2014727866 cites W2090728933 @default.
- W2014727866 cites W2097165693 @default.
- W2014727866 cites W2098358387 @default.
- W2014727866 cites W2098478833 @default.
- W2014727866 cites W2099824652 @default.
- W2014727866 cites W2103048508 @default.
- W2014727866 cites W2105562119 @default.
- W2014727866 cites W2107277218 @default.
- W2014727866 cites W2108662926 @default.
- W2014727866 cites W2108790829 @default.
- W2014727866 cites W2117611012 @default.
- W2014727866 cites W2119979039 @default.
- W2014727866 cites W2120590864 @default.
- W2014727866 cites W2121983892 @default.
- W2014727866 cites W2126865515 @default.
- W2014727866 cites W2134709550 @default.
- W2014727866 cites W2134789652 @default.
- W2014727866 cites W2135788501 @default.
- W2014727866 cites W2137015675 @default.
- W2014727866 cites W2141271255 @default.
- W2014727866 cites W2147867481 @default.
- W2014727866 cites W2148047088 @default.
- W2014727866 cites W2151529586 @default.
- W2014727866 cites W2151777569 @default.
- W2014727866 cites W2154408371 @default.
- W2014727866 cites W2158958374 @default.
- W2014727866 cites W2170112191 @default.
- W2014727866 cites W2170820215 @default.
- W2014727866 cites W2317798239 @default.
- W2014727866 doi "https://doi.org/10.1371/journal.pone.0054934" @default.
- W2014727866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3557282" @default.
- W2014727866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23383004" @default.
- W2014727866 hasPublicationYear "2013" @default.
- W2014727866 type Work @default.
- W2014727866 sameAs 2014727866 @default.
- W2014727866 citedByCount "56" @default.
- W2014727866 countsByYear W20147278662013 @default.
- W2014727866 countsByYear W20147278662014 @default.
- W2014727866 countsByYear W20147278662015 @default.
- W2014727866 countsByYear W20147278662016 @default.
- W2014727866 countsByYear W20147278662017 @default.
- W2014727866 countsByYear W20147278662018 @default.
- W2014727866 countsByYear W20147278662019 @default.
- W2014727866 countsByYear W20147278662020 @default.
- W2014727866 countsByYear W20147278662021 @default.
- W2014727866 countsByYear W20147278662022 @default.
- W2014727866 crossrefType "journal-article" @default.
- W2014727866 hasAuthorship W2014727866A5004434870 @default.
- W2014727866 hasAuthorship W2014727866A5023772384 @default.
- W2014727866 hasAuthorship W2014727866A5035482159 @default.
- W2014727866 hasAuthorship W2014727866A5062680029 @default.
- W2014727866 hasAuthorship W2014727866A5076305949 @default.
- W2014727866 hasAuthorship W2014727866A5089228213 @default.
- W2014727866 hasBestOaLocation W20147278661 @default.
- W2014727866 hasConcept C104317684 @default.
- W2014727866 hasConcept C153726182 @default.
- W2014727866 hasConcept C159047783 @default.
- W2014727866 hasConcept C2776118409 @default.