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- W2014728340 abstract "Photodynamic therapy (PDT) is gradually gaining widespread acceptance as an alternative or adjunct therapy to standard oncologic treatment modalities. Effective PDT treatment is dependent on the interaction of the photosensitizer, treatment light, and molecular oxygen. Much room for improvement exists in the area of PDT dosimetry, especially for deep-seated tumors. To this end, multi-sensory fiber optic probes that detect the fluence rate have been developed. Selected fluorophores are placed in grooves at multiple (1-5) positions along a 250micrometers optical fiber. PLS-based deconvolution of the detected fluorescence emission spectrum yields the fluorescence intensity, and hence the fluence rate, at each sensor location. Single- fluorophore probes were used to elucidate properties of individual sensors. Results with these single-sensor probes, performance with PLS-based algorithm, and preliminary performance of multi-sensor probes will be presented.© (2002) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only." @default.
- W2014728340 created "2016-06-24" @default.
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- W2014728340 date "2002-06-06" @default.
- W2014728340 modified "2023-09-23" @default.
- W2014728340 title "<title>Multisensory fiber optic probes for PDT dosimetry: construction, performance, and error analysis</title>" @default.
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- W2014728340 doi "https://doi.org/10.1117/12.469334" @default.
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