FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014729295> ?p ?o ?g. }

• W2014729295 endingPage "46" @default.
• W2014729295 startingPage "39" @default.
• W2014729295 abstract "We have recently shown that carbon monoxide releasing molecule (CORM)-A1 prevents type 1 diabetes induced in C57BL/6 mice with multiple low doses of streptozotocin (MLDS) by shifting the Th1/Th17/M1 balance towards a Th2/M2 response. In the present work we tested the hypothesis that CORM-A1 might influence regulatory arm of the immune response, as well as beta cell regeneration. CORM-A1 (2 mg/kg/day) was administered for 10 days to mice induced with MLDS and/or depleted of low dose cyclophosphamide (CY)-sensitive FoxP3+ T regulatory (Treg) cells. Besides monitoring hyperglycaemia, ex vivo analysis of spleen, pancreatic lymph nodes (PLN) and pancreas was performed at the end of treatment. In CORM-A1-treated MLDS-induced mice the improvement of hyperglycaemia was observed only without depletion of CY-sensitive FoxP3+ Treg cells. This was accompanied by decreased levels of interleukin (IL)-12, IL-2 and early activation marker CD25 in the spleen and PLN and increased transforming growth factor (TGF)-β, resulting in reduced lymphocyte proliferation in both organs. In parallel, decreased transcript levels of IL-2, but increased mRNA expression of TGF-β, accompanied with up-regulation of Ki-67 protein expression was observed within pancreas. Together, the data suggested that besides the immunomodulatory potential, CORM-A1 probably induces beta cell regeneration." @default.
• W2014729295 created "2016-06-24" @default.
• W2014729295 creator A5008638842 @default.
• W2014729295 creator A5037253414 @default.
• W2014729295 creator A5059918331 @default.
• W2014729295 creator A5068222935 @default.
• W2014729295 creator A5082185876 @default.
• W2014729295 date "2015-05-01" @default.
• W2014729295 modified "2023-09-27" @default.
• W2014729295 title "Anti-diabetic actions of carbon monoxide-releasing molecule (CORM)-A1: Immunomodulation and regeneration of islet beta cells" @default.
• W2014729295 cites W1511982358 @default.
• W2014729295 cites W1532375382 @default.
• W2014729295 cites W1540020157 @default.
• W2014729295 cites W1600690434 @default.
• W2014729295 cites W1947330042 @default.
• W2014729295 cites W1963084606 @default.
• W2014729295 cites W1976645993 @default.
• W2014729295 cites W1977695959 @default.
• W2014729295 cites W1981004692 @default.
• W2014729295 cites W1981962083 @default.
• W2014729295 cites W1991999829 @default.
• W2014729295 cites W2000312541 @default.
• W2014729295 cites W2001712566 @default.
• W2014729295 cites W2004255821 @default.
• W2014729295 cites W2004763695 @default.
• W2014729295 cites W2007903893 @default.
• W2014729295 cites W2011031473 @default.
• W2014729295 cites W2011450045 @default.
• W2014729295 cites W2013263553 @default.
• W2014729295 cites W2025830376 @default.
• W2014729295 cites W2047815625 @default.
• W2014729295 cites W2049800847 @default.
• W2014729295 cites W2055747781 @default.
• W2014729295 cites W2056016033 @default.
• W2014729295 cites W2081437976 @default.
• W2014729295 cites W2086862930 @default.
• W2014729295 cites W2090163544 @default.
• W2014729295 cites W2102617156 @default.
• W2014729295 cites W2109817133 @default.
• W2014729295 cites W2118029309 @default.
• W2014729295 cites W2127618177 @default.
• W2014729295 cites W2129387684 @default.
• W2014729295 cites W2132289617 @default.
• W2014729295 cites W2140661202 @default.
• W2014729295 cites W2145151859 @default.
• W2014729295 cites W2146161926 @default.
• W2014729295 cites W2148403473 @default.
• W2014729295 cites W2150272362 @default.
• W2014729295 cites W2157696856 @default.
• W2014729295 cites W4235618655 @default.
• W2014729295 doi "https://doi.org/10.1016/j.imlet.2015.03.009" @default.
• W2014729295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25839127" @default.
• W2014729295 hasPublicationYear "2015" @default.
• W2014729295 type Work @default.
• W2014729295 sameAs 2014729295 @default.
• W2014729295 citedByCount "17" @default.
• W2014729295 countsByYear W20147292952016 @default.
• W2014729295 countsByYear W20147292952017 @default.
• W2014729295 countsByYear W20147292952018 @default.
• W2014729295 countsByYear W20147292952019 @default.
• W2014729295 countsByYear W20147292952020 @default.
• W2014729295 countsByYear W20147292952021 @default.
• W2014729295 countsByYear W20147292952022 @default.
• W2014729295 countsByYear W20147292952023 @default.
• W2014729295 crossrefType "journal-article" @default.
• W2014729295 hasAuthorship W2014729295A5008638842 @default.
• W2014729295 hasAuthorship W2014729295A5037253414 @default.
• W2014729295 hasAuthorship W2014729295A5059918331 @default.
• W2014729295 hasAuthorship W2014729295A5068222935 @default.
• W2014729295 hasAuthorship W2014729295A5082185876 @default.
• W2014729295 hasConcept C126322002 @default.
• W2014729295 hasConcept C134018914 @default.
• W2014729295 hasConcept C165220095 @default.
• W2014729295 hasConcept C185592680 @default.
• W2014729295 hasConcept C203014093 @default.
• W2014729295 hasConcept C2776090121 @default.
• W2014729295 hasConcept C2778296632 @default.
• W2014729295 hasConcept C2778764654 @default.
• W2014729295 hasConcept C2779306644 @default.
• W2014729295 hasConcept C2779727006 @default.
• W2014729295 hasConcept C2780931953 @default.
• W2014729295 hasConcept C71924100 @default.
• W2014729295 hasConcept C79484868 @default.
• W2014729295 hasConcept C86803240 @default.
• W2014729295 hasConcept C8891405 @default.
• W2014729295 hasConceptScore W2014729295C126322002 @default.
• W2014729295 hasConceptScore W2014729295C134018914 @default.
• W2014729295 hasConceptScore W2014729295C165220095 @default.
• W2014729295 hasConceptScore W2014729295C185592680 @default.
• W2014729295 hasConceptScore W2014729295C203014093 @default.
• W2014729295 hasConceptScore W2014729295C2776090121 @default.
• W2014729295 hasConceptScore W2014729295C2778296632 @default.
• W2014729295 hasConceptScore W2014729295C2778764654 @default.
• W2014729295 hasConceptScore W2014729295C2779306644 @default.
• W2014729295 hasConceptScore W2014729295C2779727006 @default.
• W2014729295 hasConceptScore W2014729295C2780931953 @default.
• W2014729295 hasConceptScore W2014729295C71924100 @default.
• W2014729295 hasConceptScore W2014729295C79484868 @default.

• next