FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014729451> ?p ?o ?g. }

• W2014729451 endingPage "e54556" @default.
• W2014729451 startingPage "e54556" @default.
• W2014729451 abstract "Ewing Family Tumors (Ewing Sarcoma and peripheral Primitive Neuroectodermal Tumor) are common bone and soft tissue malignancies of childhood, adolescence and young adulthood. Chromosomal translocation in these tumors produces fusion oncogenes of the EWS/ETS class, with EWS/FLI1 being by far the most common. EWS/ETS chimera are the only well established driver mutations in these tumors and they function as aberrant transcription factors. Understanding the downstream genes whose expression is modified has been a central approach to the study of these tumors. FOXM1 is a proliferation associated transcription factor which has increasingly been found to play a role in the pathogenesis of a wide range of human cancers. Here we demonstrate that FOXM1 is expressed in Ewing primary tumors and cell lines. Reduction in FOXM1 expression in Ewing cell lines results in diminished potential for anchorage independent growth. FOXM1 expression is enhanced by EWS/FLI1, though, unlike other tumor systems, it is not driven by expression of the EWS/FLI1 target GLI1. Thiostrepton is a compound known to inhibit FOXM1 by direct binding. We show that Thiostrepton diminishes FOXM1 expression in Ewing cell lines and this reduction reduces cell viability through an apoptotic mechanism. FOXM1 is involved in Ewing tumor pathogenesis and may prove to be a useful therapeutic target in Ewing tumors." @default.
• W2014729451 created "2016-06-24" @default.
• W2014729451 creator A5000973128 @default.
• W2014729451 creator A5020544186 @default.
• W2014729451 creator A5048406670 @default.
• W2014729451 creator A5058923576 @default.
• W2014729451 creator A5081841674 @default.
• W2014729451 creator A5082247570 @default.
• W2014729451 date "2013-01-24" @default.
• W2014729451 modified "2023-09-25" @default.
• W2014729451 title "FOXM1 Is an Oncogenic Mediator in Ewing Sarcoma" @default.
• W2014729451 cites W1789215739 @default.
• W2014729451 cites W1963493384 @default.
• W2014729451 cites W1969037652 @default.
• W2014729451 cites W1970041667 @default.
• W2014729451 cites W1972926597 @default.
• W2014729451 cites W1976420641 @default.
• W2014729451 cites W1978326263 @default.
• W2014729451 cites W1984708567 @default.
• W2014729451 cites W1987986416 @default.
• W2014729451 cites W1995745247 @default.
• W2014729451 cites W2002512110 @default.
• W2014729451 cites W2007438323 @default.
• W2014729451 cites W2008979678 @default.
• W2014729451 cites W2010962756 @default.
• W2014729451 cites W2014756186 @default.
• W2014729451 cites W2025989401 @default.
• W2014729451 cites W2032481064 @default.
• W2014729451 cites W2034091087 @default.
• W2014729451 cites W2034729360 @default.
• W2014729451 cites W2038626783 @default.
• W2014729451 cites W2042889829 @default.
• W2014729451 cites W2050717449 @default.
• W2014729451 cites W2051833743 @default.
• W2014729451 cites W2058396569 @default.
• W2014729451 cites W2069351898 @default.
• W2014729451 cites W2092784915 @default.
• W2014729451 cites W2097906998 @default.
• W2014729451 cites W2103953796 @default.
• W2014729451 cites W2118369424 @default.
• W2014729451 cites W2124006755 @default.
• W2014729451 cites W2126812050 @default.
• W2014729451 cites W2135140338 @default.
• W2014729451 cites W2138897067 @default.
• W2014729451 cites W2153553059 @default.
• W2014729451 cites W2154345686 @default.
• W2014729451 cites W2166639324 @default.
• W2014729451 cites W2168955110 @default.
• W2014729451 cites W2170407716 @default.
• W2014729451 cites W2171293990 @default.
• W2014729451 doi "https://doi.org/10.1371/journal.pone.0054556" @default.
• W2014729451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3554707" @default.
• W2014729451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23365673" @default.
• W2014729451 hasPublicationYear "2013" @default.
• W2014729451 type Work @default.
• W2014729451 sameAs 2014729451 @default.
• W2014729451 citedByCount "32" @default.
• W2014729451 countsByYear W20147294512013 @default.
• W2014729451 countsByYear W20147294512014 @default.
• W2014729451 countsByYear W20147294512015 @default.
• W2014729451 countsByYear W20147294512016 @default.
• W2014729451 countsByYear W20147294512017 @default.
• W2014729451 countsByYear W20147294512018 @default.
• W2014729451 countsByYear W20147294512019 @default.
• W2014729451 countsByYear W20147294512020 @default.
• W2014729451 countsByYear W20147294512022 @default.
• W2014729451 crossrefType "journal-article" @default.
• W2014729451 hasAuthorship W2014729451A5000973128 @default.
• W2014729451 hasAuthorship W2014729451A5020544186 @default.
• W2014729451 hasAuthorship W2014729451A5048406670 @default.
• W2014729451 hasAuthorship W2014729451A5058923576 @default.
• W2014729451 hasAuthorship W2014729451A5081841674 @default.
• W2014729451 hasAuthorship W2014729451A5082247570 @default.
• W2014729451 hasBestOaLocation W20147294511 @default.
• W2014729451 hasConcept C104317684 @default.
• W2014729451 hasConcept C111829193 @default.
• W2014729451 hasConcept C142724271 @default.
• W2014729451 hasConcept C170240278 @default.
• W2014729451 hasConcept C2777578258 @default.
• W2014729451 hasConcept C2777586341 @default.
• W2014729451 hasConcept C2777937962 @default.
• W2014729451 hasConcept C2778256501 @default.
• W2014729451 hasConcept C502942594 @default.
• W2014729451 hasConcept C54355233 @default.
• W2014729451 hasConcept C62112901 @default.
• W2014729451 hasConcept C67705224 @default.
• W2014729451 hasConcept C71924100 @default.
• W2014729451 hasConcept C86339819 @default.
• W2014729451 hasConcept C86803240 @default.
• W2014729451 hasConcept C88478588 @default.
• W2014729451 hasConceptScore W2014729451C104317684 @default.
• W2014729451 hasConceptScore W2014729451C111829193 @default.
• W2014729451 hasConceptScore W2014729451C142724271 @default.
• W2014729451 hasConceptScore W2014729451C170240278 @default.
• W2014729451 hasConceptScore W2014729451C2777578258 @default.
• W2014729451 hasConceptScore W2014729451C2777586341 @default.
• W2014729451 hasConceptScore W2014729451C2777937962 @default.
• W2014729451 hasConceptScore W2014729451C2778256501 @default.

• next