FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014736356> ?p ?o ?g. }

• W2014736356 endingPage "33" @default.
• W2014736356 startingPage "25" @default.
• W2014736356 abstract "Objectives: Bexarotene is a synthetic retinoid used for treatment of neoplastic or dermatologic disorders. Based on the retinoid dysregulation hypothesis, it was hypothesized that bexarotene augmentation would have a beneficial effect in the antipsychotic treatment of schizophrenia patients. This study is the first to investigate the safety and efficacy of add-on oral bexarotene to ongoing antipsychotic treatment in chronic schizophrenia patients who were stabilized on regular antipsychotic treatment. Methods: A 6-week open label trial was conducted in 2 mental health centers from October 2005 to October 2006. Twenty-five patients with chronic schizophrenia received a low dose of bexarotene (75 mg/d) augmentation. Mental condition and laboratory tests were assessed at baseline and after weeks 2, 4, and 6 of the study. The primary outcome measure was change from baseline in 4 symptom scales: the Positive and Negative Symptom Scale, Extrapyramidal Symptom Rating Scale, Abnormal Involuntary Movement Scale, and Barnes Akathisia Scale. Blood cell count, liver and thyroid functions, cholesterol, and triglyceride rates were followed. Results: Significant improvement from baseline to endpoint was observed on total Positive and Negative Symptom Scale score (P = 0.022), general psychopathology (P = 0.024), positive (P = 0.012), and the dysphoric mood (P = 0.028) factor scores. Furthermore, a trend to a diminishing Extrapyramidal Symptom Rating Scale score (P = 0.053) was found. Bexarotene was found to be a safe medication as measured by all laboratory parameters with the exception of increased total cholesterol serum level. Conclusions: This short-term pilot study supports bexarotene as a potential valuable adjunct in management of schizophrenia. Low doses of bexarotene were well tolerated. A double-blind controlled study should be performed to replicate these preliminary positive results." @default.
• W2014736356 created "2016-06-24" @default.
• W2014736356 creator A5013392825 @default.
• W2014736356 creator A5017864703 @default.
• W2014736356 creator A5028436352 @default.
• W2014736356 creator A5059532230 @default.
• W2014736356 creator A5061641698 @default.
• W2014736356 creator A5070239766 @default.
• W2014736356 creator A5088156729 @default.
• W2014736356 date "2008-01-01" @default.
• W2014736356 modified "2023-09-26" @default.
• W2014736356 title "Bexarotene as Add-On to Antipsychotic Treatment in Schizophrenia Patients" @default.
• W2014736356 cites W1899283284 @default.
• W2014736356 cites W1963580478 @default.
• W2014736356 cites W1966165057 @default.
• W2014736356 cites W1966316797 @default.
• W2014736356 cites W1969968664 @default.
• W2014736356 cites W1974283351 @default.
• W2014736356 cites W1976405146 @default.
• W2014736356 cites W1979887383 @default.
• W2014736356 cites W1993921528 @default.
• W2014736356 cites W1994109490 @default.
• W2014736356 cites W1999689270 @default.
• W2014736356 cites W2001515160 @default.
• W2014736356 cites W2011681931 @default.
• W2014736356 cites W2012863812 @default.
• W2014736356 cites W2014250215 @default.
• W2014736356 cites W2018740809 @default.
• W2014736356 cites W2024527855 @default.
• W2014736356 cites W2050670207 @default.
• W2014736356 cites W2060473560 @default.
• W2014736356 cites W2067732057 @default.
• W2014736356 cites W2070430949 @default.
• W2014736356 cites W2071230039 @default.
• W2014736356 cites W2076895783 @default.
• W2014736356 cites W2092136583 @default.
• W2014736356 cites W2106489915 @default.
• W2014736356 cites W2114987540 @default.
• W2014736356 cites W2119137992 @default.
• W2014736356 cites W2122827236 @default.
• W2014736356 cites W2125577585 @default.
• W2014736356 cites W2140606211 @default.
• W2014736356 cites W2140915307 @default.
• W2014736356 cites W2141478391 @default.
• W2014736356 cites W2142161937 @default.
• W2014736356 cites W2171122740 @default.
• W2014736356 doi "https://doi.org/10.1097/wnf.0b013e31806450da" @default.
• W2014736356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18303488" @default.
• W2014736356 hasPublicationYear "2008" @default.
• W2014736356 type Work @default.
• W2014736356 sameAs 2014736356 @default.
• W2014736356 citedByCount "37" @default.
• W2014736356 countsByYear W20147363562012 @default.
• W2014736356 countsByYear W20147363562013 @default.
• W2014736356 countsByYear W20147363562014 @default.
• W2014736356 countsByYear W20147363562015 @default.
• W2014736356 countsByYear W20147363562016 @default.
• W2014736356 countsByYear W20147363562017 @default.
• W2014736356 countsByYear W20147363562018 @default.
• W2014736356 countsByYear W20147363562019 @default.
• W2014736356 countsByYear W20147363562020 @default.
• W2014736356 countsByYear W20147363562022 @default.
• W2014736356 countsByYear W20147363562023 @default.
• W2014736356 crossrefType "journal-article" @default.
• W2014736356 hasAuthorship W2014736356A5013392825 @default.
• W2014736356 hasAuthorship W2014736356A5017864703 @default.
• W2014736356 hasAuthorship W2014736356A5028436352 @default.
• W2014736356 hasAuthorship W2014736356A5059532230 @default.
• W2014736356 hasAuthorship W2014736356A5061641698 @default.
• W2014736356 hasAuthorship W2014736356A5070239766 @default.
• W2014736356 hasAuthorship W2014736356A5088156729 @default.
• W2014736356 hasConcept C104317684 @default.
• W2014736356 hasConcept C118552586 @default.
• W2014736356 hasConcept C126322002 @default.
• W2014736356 hasConcept C15744967 @default.
• W2014736356 hasConcept C2776412080 @default.
• W2014736356 hasConcept C2776921671 @default.
• W2014736356 hasConcept C2777393122 @default.
• W2014736356 hasConcept C2778528637 @default.
• W2014736356 hasConcept C2778820923 @default.
• W2014736356 hasConcept C2779727114 @default.
• W2014736356 hasConcept C2780135775 @default.
• W2014736356 hasConcept C2780494398 @default.
• W2014736356 hasConcept C2780616385 @default.
• W2014736356 hasConcept C55493867 @default.
• W2014736356 hasConcept C63932345 @default.
• W2014736356 hasConcept C71924100 @default.
• W2014736356 hasConcept C86339819 @default.
• W2014736356 hasConcept C86803240 @default.
• W2014736356 hasConceptScore W2014736356C104317684 @default.
• W2014736356 hasConceptScore W2014736356C118552586 @default.
• W2014736356 hasConceptScore W2014736356C126322002 @default.
• W2014736356 hasConceptScore W2014736356C15744967 @default.
• W2014736356 hasConceptScore W2014736356C2776412080 @default.
• W2014736356 hasConceptScore W2014736356C2776921671 @default.
• W2014736356 hasConceptScore W2014736356C2777393122 @default.
• W2014736356 hasConceptScore W2014736356C2778528637 @default.
• W2014736356 hasConceptScore W2014736356C2778820923 @default.

• next