FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014736504> ?p ?o ?g. }

• W2014736504 endingPage "2215" @default.
• W2014736504 startingPage "2215" @default.
• W2014736504 abstract "Up to one third of patients who undergo total knee replacement develop deep vein thrombosis after surgery despite receiving low-molecular-weight heparin prophylaxis. Ximelagatran is a novel direct inhibitor of free and clot-bound thrombin.We performed a randomized, parallel, dose-finding study of 600 adults undergoing elective total knee replacement at 68 North American hospitals to determine the optimum dose of ximelagatran to use as prophylaxis against venous thromboembolism after total knee replacement. Patients received either ximelagatran twice daily by mouth in blinded fixed doses of 8, 12, 18, or 24 mg or open-label enoxaparin sodium, 30 mg, subcutaneously twice daily, starting 12 to 24 hours after surgery and continuing for 6 to 12 days. We measured the 6- to 12-day cumulative incidence of symptomatic or venographic deep vein thrombosis, symptomatic pulmonary embolism, and bleeding.A total of 594 patients received at least 1 dose of the study drug; 443 patients were evaluable for efficacy. Rates of overall venous thromboembolism (and proximal deep vein thrombosis or pulmonary embolism) for the 8-, 12-, 18-, and 24-mg doses of ximelagatran were 27% (6.6%), 19.8% (2.0%), 28.7% (5.8%), and 15.8% (3.2%), respectively. Rates of overall venous thromboembolism (22.7%) and proximal deep vein thrombosis or pulmonary embolism (3.1%) for enoxaparin did not differ significantly compared with 24-mg ximelagatran (overall difference, -6.9%; 95% confidence interval, -18.0% to 4.2%; P=.3). There was no major bleeding with administration of 24 mg of ximelagatran twice daily.Fixed-dose, unmonitored ximelagatran, 24 mg twice daily, given after surgery appears to be safe and effective oral prophylaxis against venous thromboembolism after total knee replacement." @default.
• W2014736504 created "2016-06-24" @default.
• W2014736504 creator A5000127045 @default.
• W2014736504 creator A5002442157 @default.
• W2014736504 creator A5013909915 @default.
• W2014736504 creator A5055052720 @default.
• W2014736504 creator A5055785288 @default.
• W2014736504 creator A5061723576 @default.
• W2014736504 creator A5088267718 @default.
• W2014736504 date "2001-10-08" @default.
• W2014736504 modified "2023-10-17" @default.
• W2014736504 title "Comparison of the Oral Direct Thrombin Inhibitor Ximelagatran With Enoxaparin as Prophylaxis Against Venous Thromboembolism After Total Knee Replacement" @default.
• W2014736504 cites W1822603823 @default.
• W2014736504 cites W1964159013 @default.
• W2014736504 cites W1987745038 @default.
• W2014736504 cites W1991949088 @default.
• W2014736504 cites W2001204795 @default.
• W2014736504 cites W2010599049 @default.
• W2014736504 cites W2048032060 @default.
• W2014736504 cites W2071155706 @default.
• W2014736504 cites W2138849164 @default.
• W2014736504 cites W2143230270 @default.
• W2014736504 cites W2158402473 @default.
• W2014736504 cites W2220791434 @default.
• W2014736504 cites W2341200743 @default.
• W2014736504 cites W2424887566 @default.
• W2014736504 cites W2611712684 @default.
• W2014736504 doi "https://doi.org/10.1001/archinte.161.18.2215" @default.
• W2014736504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11575978" @default.
• W2014736504 hasPublicationYear "2001" @default.
• W2014736504 type Work @default.
• W2014736504 sameAs 2014736504 @default.
• W2014736504 citedByCount "155" @default.
• W2014736504 countsByYear W20147365042013 @default.
• W2014736504 countsByYear W20147365042014 @default.
• W2014736504 countsByYear W20147365042015 @default.
• W2014736504 countsByYear W20147365042016 @default.
• W2014736504 countsByYear W20147365042017 @default.
• W2014736504 countsByYear W20147365042018 @default.
• W2014736504 countsByYear W20147365042021 @default.
• W2014736504 crossrefType "journal-article" @default.
• W2014736504 hasAuthorship W2014736504A5000127045 @default.
• W2014736504 hasAuthorship W2014736504A5002442157 @default.
• W2014736504 hasAuthorship W2014736504A5013909915 @default.
• W2014736504 hasAuthorship W2014736504A5055052720 @default.
• W2014736504 hasAuthorship W2014736504A5055785288 @default.
• W2014736504 hasAuthorship W2014736504A5061723576 @default.
• W2014736504 hasAuthorship W2014736504A5088267718 @default.
• W2014736504 hasConcept C126322002 @default.
• W2014736504 hasConcept C141071460 @default.
• W2014736504 hasConcept C2776265017 @default.
• W2014736504 hasConcept C2776301958 @default.
• W2014736504 hasConcept C2776710957 @default.
• W2014736504 hasConcept C2776884760 @default.
• W2014736504 hasConcept C2778104916 @default.
• W2014736504 hasConcept C2778205648 @default.
• W2014736504 hasConcept C2778336525 @default.
• W2014736504 hasConcept C2778810321 @default.
• W2014736504 hasConcept C2778825682 @default.
• W2014736504 hasConcept C2778959117 @default.
• W2014736504 hasConcept C2779161974 @default.
• W2014736504 hasConcept C2779630707 @default.
• W2014736504 hasConcept C2780011451 @default.
• W2014736504 hasConcept C2780868729 @default.
• W2014736504 hasConcept C42219234 @default.
• W2014736504 hasConcept C71924100 @default.
• W2014736504 hasConceptScore W2014736504C126322002 @default.
• W2014736504 hasConceptScore W2014736504C141071460 @default.
• W2014736504 hasConceptScore W2014736504C2776265017 @default.
• W2014736504 hasConceptScore W2014736504C2776301958 @default.
• W2014736504 hasConceptScore W2014736504C2776710957 @default.
• W2014736504 hasConceptScore W2014736504C2776884760 @default.
• W2014736504 hasConceptScore W2014736504C2778104916 @default.
• W2014736504 hasConceptScore W2014736504C2778205648 @default.
• W2014736504 hasConceptScore W2014736504C2778336525 @default.
• W2014736504 hasConceptScore W2014736504C2778810321 @default.
• W2014736504 hasConceptScore W2014736504C2778825682 @default.
• W2014736504 hasConceptScore W2014736504C2778959117 @default.
• W2014736504 hasConceptScore W2014736504C2779161974 @default.
• W2014736504 hasConceptScore W2014736504C2779630707 @default.
• W2014736504 hasConceptScore W2014736504C2780011451 @default.
• W2014736504 hasConceptScore W2014736504C2780868729 @default.
• W2014736504 hasConceptScore W2014736504C42219234 @default.
• W2014736504 hasConceptScore W2014736504C71924100 @default.
• W2014736504 hasIssue "18" @default.
• W2014736504 hasLocation W20147365041 @default.
• W2014736504 hasLocation W20147365042 @default.
• W2014736504 hasOpenAccess W2014736504 @default.
• W2014736504 hasPrimaryLocation W20147365041 @default.
• W2014736504 hasRelatedWork W2001032223 @default.
• W2014736504 hasRelatedWork W2014736504 @default.
• W2014736504 hasRelatedWork W2050364432 @default.
• W2014736504 hasRelatedWork W2326914415 @default.
• W2014736504 hasRelatedWork W4243020401 @default.
• W2014736504 hasRelatedWork W4249109694 @default.
• W2014736504 hasRelatedWork W4367483743 @default.
• W2014736504 hasRelatedWork W4386104923 @default.
• W2014736504 hasRelatedWork W189952345 @default.

• next