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• W2014740064 abstract "Background In the chronic established periodontal lesion, the proliferation and migration potential of periodontal ligament (PDL) cells are significantly compromised. Thus, the progressive loss of tissue integrity is favored and normal healing and regeneration compromised. Periostin, a known PDL marker, modulates cell–matrix interactions, cell behavior, as well as the matrix biomechanics and PDL homeostasis. Objective To evaluate whether periostin restores the regenerative potential of PDL cells in terms of proliferation, migration, and activation of survival signaling pathways after being challenged by Porphyromonas gingivalis lipopolysaccharides and tumor necrosis factor alpha α. Methods Human PDL (hPDL) cells were cultured under different conditions: control, periostin (50 or 100 ng/mL), and fibroblast growth factor 2 (10 ng/mL) to evaluate cell proliferation (by Ki67), cell migration (by scratch assays) and PI3K/AKT/mTOR pathway activation (by western blot analyses of total AKT, phospho-AKT and PS6). A different set of cultures was challenged by adding tumor necrosis factor alpha α (10 ng/mL) and P. gingivalis lipopolysaccharides (200 ng/mL) to evaluate the effects of periostin as described above. Results Periostin significantly increased cell proliferation (twofold), migration (especially at earlier time points and low dose) and activation of survival signaling pathway (higher phosphorylation of AKT and PS6). Furthermore, periostin promoted similar cellular effects even after being challenged with proinflammatory cytokines and bacterial virulence factors. Conclusion Periostin acts as an important modulator of hPDL cell–matrix dynamics. It modulates hPDL proliferation, migration and PI3K/AKT/mTOR pathway. It also helps in overcoming the altered biological phenotype that chronic exposure to periodontal pathogens and proinflammatory cytokines produce in hPDL cells." @default.
• W2014740064 created "2016-06-24" @default.
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• W2014740064 date "2013-08-06" @default.
• W2014740064 modified "2023-09-26" @default.
• W2014740064 title "Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor -α and <i>Porphyromonas </i> <i>gingivalis </i> lipopolysaccharides" @default.
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• W2014740064 doi "https://doi.org/10.1111/jre.12120" @default.
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