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- W2014741479 abstract "This study records the first observations in human beings on the hemodynamic effects of diphenylhydantoin (DPH). Alterations were not noted in cardiac output, peripheral resistance, pulmonary pressures, or the electrocardiogram when the drug was administered in doses previously noted to be clinically effective in cardiac arrhythmias. Animal studies have shown that DPH directly reduces ventricular function and results in vasodilatation, but that the cardiovascular toxicity is probably related more to the rapidity of injection than to the absolute dose. The pharmacologic actions of DPH resemble those of quinidine and procainamide, with the exception that DPH has not been shown to be effective against chronic atrial flutter and fibrillation, and that in small doses it may greatly augment vagal tone. The conclusion is that, in this study, even though DPH did not significantly alter cardiovascular function, it possesses significant toxic potential, and should be administered cautiously and in doses not exceeding 10 mg. per kilogram." @default.
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- W2014741479 date "1967-04-01" @default.
- W2014741479 modified "2023-09-23" @default.
- W2014741479 title "The hemodynamic effects of diphenylhydantoin" @default.
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- W2014741479 doi "https://doi.org/10.1016/0002-8703(67)90205-0" @default.
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