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- W2014744211 abstract "Left ventricular (LV) myocardial slices were isolated from murine hearts (300 μm thick) and were stimulated at 1 Hz without external load. Mean myocardial slice O 2 consumption (MVo 2 ) per minute (mMVo 2 ) without stimulation was 0.97 ± 0.14 ml O 2 ·min −1 ·100 g LV −1 and mean mMVo 2 with stimulation increased to 1.80 ± 0.17 ml O 2 ·min −1 ·100 g LV −1 in normal Tyrode solution. Mean ΔmVo 2 (the mMVo 2 with stimulation − the mMVo 2 without stimulation) was 0.83 ± 0.12 ml O 2 ·min −1 ·100 g LV −1 . There were no differences between mean mMVo 2 with and without stimulation in Ca 2+ -free solution. The increases in extracellular Ca 2+ concentrations up to 14.4 mM did not affect the mMVo 2 without stimulation but significantly increased the mMVo 2 with stimulation up to 140% of control. The ΔmMVo 2 significantly increased up to 190% of the control in a dose-dependent manner. In contrast, the shortening did not increase in a dose-dependent manner. Cyclopiazonic acid (CPA; 30 μM) significantly reduced the ΔmMVo 2 to 0.27 ± 0.06 ml O 2 ·min −1 ·100 g LV −1 (35% of control). The combination of 5 mM 2,3-butanedione monoxime (BDM) and 30 μM CPA did not further decrease ΔmMVo 2 . Although BDM (3–5 mM) decreased the ΔmMVo 2 by 28–30% of control in a dose-independent manner, 3–5 mM BDM decreased shortening in a dose-dependent manner. Our results indicate that the ΔmMVo 2 of mouse LV slices during shortening under mechanically unloaded conditions consists of energy expenditure for total Ca 2+ handling during excitation-contraction coupling, basal metabolism, but no residual cross-bridge cycling." @default.
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- W2014744211 date "2004-07-01" @default.
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- W2014744211 title "O<sub>2</sub> consumption of mechanically unloaded contractions of mouse left ventricular myocardial slices" @default.
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- W2014744211 doi "https://doi.org/10.1152/ajpheart.01082.2003" @default.
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