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- W2014745089 abstract "Our interest in the effect of hypoxia on the pulmonary microcirculation was its use as a tool to answer the question: what is the origin of the vascular smooth muscle (VSM) of the pulmonary arterioles in adult pulmonary hypertension? Although “true” pulmonary arterioles are not present in the adult mammalian lung, 1 Brenner O Pathology of the vessels of the pulmonary circulation. Arch Intern Med. 1935; 56: 211-337 Crossref Scopus (55) Google Scholar traces of VSM persist even in the aged lung arterioles. 2 Sobin SS Lindal RG Bernick S The pulmonary arteriole. Microvasc Res. 1977; 14: 227-239 Crossref PubMed Scopus (8) Google Scholar We wished to distinguish between possible recall or activation of VSM and the de nova formation of VSM and believed that hypoxic challenge was an appropriate tool. With 10% O2 in nitrogen or ½ atm exposure, we found rapid changes in the prealveolar (acinar) arterioles of less than 30 μ diameter. 3 Sobin SS Tremer HM Hardy JH Chiodi HP Changes in arteriole in acute and chronic hypoxic pulmonary hypertension and recovery in rat. J Appl Physiol. 1963; 55: 1445-1455 Google Scholar Blebs developed between the endothelium and its basal lamina, and edema occurred in the arteriolar wall connective tissue. These were present after 1 h of hypoxia (Fig 1); 5% O2 produced similar changes after only 15 min. Fibroblasts, normally present in the arteriolar wall at the intercept with the alveolar wall, tripled in number by 24 h, migrated subendothelially, and during the next 24–48 h developed a basal lamina, myofibrils, lost their rich endoplasmic reticulum, and completed their transformation into typical VSM by 3–4 days. The endothelium of these muscularized vessels appeared normal after 48 h. These changes of subendothelial blebbing, wall edema, and increased number of fibroblasts were not present in the capillary bed, small venules, or proximal small arteries. The number of platelets per arteriolar cross-section increased by 24 h and peaked at 48 h, with an ocsasional platelet adherent to the endothelium." @default.
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- W2014745089 title "Hypoxia and the Pulmonary Microvasculature" @default.
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- W2014745089 doi "https://doi.org/10.1378/chest.93.3_supplement.155s" @default.
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